Xu S - Search Results

1

Discovery of a potent and selective proteolysis targeting chimera (PROTAC) degrader of NSD3 histone methyltransferase.

Sun Y, Zhang Y, Chen X, Yu A, Du W, Huang Y, Wu F, Yu L, Li J, Wen C, Yang H, Shi Q, Geng M, Huang X, Xu S. Sun Y, et al. Among authors: xu s. Eur J Med Chem. 2022 Sep 5;239:114528. doi: 10.1016/j.ejmech.2022.114528. Epub 2022 Jun 13. Eur J Med Chem. 2022. PMID: 35717870

2

Design, synthesis, and biological evaluation of novel conformationally constrained inhibitors targeting epidermal growth factor receptor threonine⁷⁹⁰ → methionine⁷⁹⁰ mutant.

Chang S, Zhang L, Xu S, Luo J, Lu X, Zhang Z, Xu T, Liu Y, Tu Z, Xu Y, Ren X, Geng M, Ding J, Pei D, Ding K. Chang S, et al. Among authors: xu s, xu t, xu y. J Med Chem. 2012 Mar 22;55(6):2711-23. doi: 10.1021/jm201591k. Epub 2012 Mar 1. J Med Chem. 2012. PMID: 22339342

3

1-Phenyl-4-benzoyl-1H-1,2,3-triazoles as orally bioavailable transcriptional function suppressors of estrogen-related receptor α.

Xu S, Zhuang X, Pan X, Zhang Z, Duan L, Liu Y, Zhang L, Ren X, Ding K. Xu S, et al. J Med Chem. 2013 Jun 13;56(11):4631-40. doi: 10.1021/jm4003928. Epub 2013 May 24. J Med Chem. 2013. PMID: 23656512

4

1-Benzyl-4-phenyl-1H-1,2,3-triazoles improve the transcriptional functions of estrogen-related receptor γ and promote the browning of white adipose.

Xu S, Mao L, Ding P, Zhuang X, Zhou Y, Yu L, Liu Y, Nie T, Xu T, Xu Y, Liu J, Smaill J, Ren X, Wu D, Ding K. Xu S, et al. Among authors: xu t, xu y. Bioorg Med Chem. 2015 Jul 1;23(13):3751-60. doi: 10.1016/j.bmc.2015.03.082. Epub 2015 Apr 9. Bioorg Med Chem. 2015. PMID: 25910584

5

Discovery of a potent, selective, and covalent ZAP-70 kinase inhibitor.

Rao D, Li H, Ren X, Sun Y, Wen C, Zheng M, Huang H, Tang W, Xu S. Rao D, et al. Among authors: xu s. Eur J Med Chem. 2021 Jul 5;219:113393. doi: 10.1016/j.ejmech.2021.113393. Epub 2021 Mar 30. Eur J Med Chem. 2021. PMID: 33845236

6

Luteolin promotes macrophage-mediated phagocytosis by inhibiting CD47 pyroglutamation.

Li Z, Gu X, Rao D, Lu M, Wen J, Chen X, Wang H, Cui X, Tang W, Xu S, Wang P, Yu L, Ge X. Li Z, et al. Among authors: xu s. Transl Oncol. 2021 Aug;14(8):101129. doi: 10.1016/j.tranon.2021.101129. Epub 2021 May 26. Transl Oncol. 2021. PMID: 34051623 Free PMC article.

7

Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.

Zhang M, Aguilar A, Xu S, Huang L, Chinnaswamy K, Sleger T, Wang B, Gross S, Nicolay BN, Ronseaux S, Harvey K, Wang Y, McEachern D, Kirchhoff PD, Liu Z, Stuckey J, Tron AE, Liu T, Wang S. Zhang M, et al. Among authors: xu s. J Med Chem. 2021 Jul 22;64(14):10333-10349. doi: 10.1021/acs.jmedchem.1c00789. Epub 2021 Jul 1. J Med Chem. 2021. PMID: 34196551 Free PMC article.

8

Structure-Based Discovery of a Series of NSD2-PWWP1 Inhibitors.

Li N, Yang H, Liu K, Zhou L, Huang Y, Cao D, Li Y, Sun Y, Yu A, Du Z, Yu F, Zhang Y, Wang B, Geng M, Li J, Xiong B, Xu S, Huang X, Liu T. Li N, et al. Among authors: xu s. J Med Chem. 2022 Jul 14;65(13):9459-9477. doi: 10.1021/acs.jmedchem.2c00709. Epub 2022 Jun 15. J Med Chem. 2022. PMID: 35704853

9

Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors.

Wu F, Li H, An Q, Sun Y, Yu J, Cao W, Sun P, Diao X, Meng L, Xu S. Wu F, et al. Among authors: xu s. Eur J Med Chem. 2023 Jun 5;254:115355. doi: 10.1016/j.ejmech.2023.115355. Epub 2023 Apr 10. Eur J Med Chem. 2023. PMID: 37062169

10

Discovery and Structural Optimization of Covalent ZAP-70 Kinase Inhibitors against Psoriasis.

Rao D, Yang T, Feng H, An Q, Zhang S, Yu J, Ren X, Diao X, Huang H, Tang W, Xu S. Rao D, et al. Among authors: xu s. J Med Chem. 2023 Sep 14;66(17):12018-12032. doi: 10.1021/acs.jmedchem.3c00606. Epub 2023 Aug 18. J Med Chem. 2023. PMID: 37594408

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