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Risk-associated alterations in marrow T cells in pediatric leukemia.
Bailur JK, McCachren SS, Pendleton K, Vasquez JC, Lim HS, Duffy A, Doxie DB, Kaushal A, Foster C, DeRyckere D, Castellino S, Kemp ML, Qiu P, Dhodapkar MV, Dhodapkar KM. Bailur JK, et al. Among authors: deryckere d. JCI Insight. 2020 Aug 20;5(16):e140179. doi: 10.1172/jci.insight.140179. JCI Insight. 2020. PMID: 32692727 Free PMC article.
Siglec-15 Promotes Evasion of Adaptive Immunity in B-cell Acute Lymphoblastic Leukemia.
Pillsbury CE, Dougan J, Rabe JL, Fonseca JA, Zhou C, Evans AN, Abukharma H, Ichoku O, Gonzalez-Flamenco G, Park SI, Aljudi A, DeRyckere D, Castellino SM, Rafiq S, Langermann S, Liu LN, Henry CJ, Porter CC. Pillsbury CE, et al. Among authors: deryckere d. Cancer Res Commun. 2023 Jul 17;3(7):1248-1259. doi: 10.1158/2767-9764.CRC-23-0056. eCollection 2023 Jul. Cancer Res Commun. 2023. PMID: 37465593 Free PMC article.
Pediatric T-cell acute lymphoblastic leukemia blast signature and MRD associated immune environment changes defined by single cell transcriptomics analysis.
Bhasin SS, Thomas BE, Summers RJ, Sarkar D, Mumme H, Pilcher W, Emam M, Raikar SS, Park SI, Castellino SM, Graham DK, Bhasin MK, DeRyckere D. Bhasin SS, et al. Among authors: deryckere d. Sci Rep. 2023 Aug 2;13(1):12556. doi: 10.1038/s41598-023-39152-z. Sci Rep. 2023. PMID: 37532715 Free PMC article.
Single-cell analysis reveals altered tumor microenvironments of relapse- and remission-associated pediatric acute myeloid leukemia.
Mumme H, Thomas BE, Bhasin SS, Krishnan U, Dwivedi B, Perumalla P, Sarkar D, Ulukaya GB, Sabnis HS, Park SI, DeRyckere D, Raikar SS, Pauly M, Summers RJ, Castellino SM, Wechsler DS, Porter CC, Graham DK, Bhasin M. Mumme H, et al. Among authors: deryckere d. Nat Commun. 2023 Oct 5;14(1):6209. doi: 10.1038/s41467-023-41994-0. Nat Commun. 2023. PMID: 37798266 Free PMC article.
UNC2025, a MERTK Small-Molecule Inhibitor, Is Therapeutically Effective Alone and in Combination with Methotrexate in Leukemia Models.
DeRyckere D, Lee-Sherick AB, Huey MG, Hill AA, Tyner JW, Jacobsen KM, Page LS, Kirkpatrick GG, Eryildiz F, Montgomery SA, Zhang W, Wang X, Frye SV, Earp HS, Graham DK. DeRyckere D, et al. Clin Cancer Res. 2017 Mar 15;23(6):1481-1492. doi: 10.1158/1078-0432.CCR-16-1330. Epub 2016 Sep 20. Clin Cancer Res. 2017. PMID: 27649555 Free PMC article.
MERTK inhibition alters the PD-1 axis and promotes anti-leukemia immunity.
Lee-Sherick AB, Jacobsen KM, Henry CJ, Huey MG, Parker RE, Page LS, Hill AA, Wang X, Frye SV, Earp HS, Jordan CT, DeRyckere D, Graham DK. Lee-Sherick AB, et al. Among authors: deryckere d. JCI Insight. 2018 Nov 2;3(21):e97941. doi: 10.1172/jci.insight.97941. JCI Insight. 2018. PMID: 30385715 Free PMC article.
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