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Drug-like Inhibitors of DC-SIGN Based on a Quinolone Scaffold.
Zhang H, Daněk O, Makarov D, Rádl S, Kim D, Ledvinka J, Vychodilová K, Hlaváč J, Lefèbre J, Denis M, Rademacher C, Ménová P. Zhang H, et al. ACS Med Chem Lett. 2022 May 10;13(6):935-942. doi: 10.1021/acsmedchemlett.2c00067. eCollection 2022 Jun 9. ACS Med Chem Lett. 2022. PMID: 35707152 Free PMC article.
A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN.
Wawrzinek R, Wamhoff EC, Lefebre J, Rentzsch M, Bachem G, Domeniconi G, Schulze J, Fuchsberger FF, Zhang H, Modenutti C, Schnirch L, Marti MA, Schwardt O, Bräutigam M, Guberman M, Hauck D, Seeberger PH, Seitz O, Titz A, Ernst B, Rademacher C. Wawrzinek R, et al. Among authors: zhang h. J Am Chem Soc. 2021 Nov 17;143(45):18977-18988. doi: 10.1021/jacs.1c07235. Epub 2021 Nov 8. J Am Chem Soc. 2021. PMID: 34748320 Free PMC article.
Protein-observed 19F NMR of LecA from Pseudomonas aeruginosa.
Shanina E, Siebs E, Zhang H, Varón Silva D, Joachim I, Titz A, Rademacher C. Shanina E, et al. Among authors: zhang h. Glycobiology. 2021 Feb 9;31(2):159-165. doi: 10.1093/glycob/cwaa057. Glycobiology. 2021. PMID: 32573695 Free PMC article.
Allosteric Inhibition of a Mammalian Lectin.
Aretz J, Anumala UR, Fuchsberger FF, Molavi N, Ziebart N, Zhang H, Nazaré M, Rademacher C. Aretz J, et al. Among authors: zhang h. J Am Chem Soc. 2018 Nov 7;140(44):14915-14925. doi: 10.1021/jacs.8b08644. Epub 2018 Oct 24. J Am Chem Soc. 2018. PMID: 30303367
The 3F Library: Fluorinated Fsp3 -Rich Fragments for Expeditious 19 F NMR Based Screening.
Troelsen NS, Shanina E, Gonzalez-Romero D, Danková D, Jensen ISA, Śniady KJ, Nami F, Zhang H, Rademacher C, Cuenda A, Gotfredsen CH, Clausen MH. Troelsen NS, et al. Among authors: zhang h. Angew Chem Int Ed Engl. 2020 Feb 3;59(6):2204-2210. doi: 10.1002/anie.201913125. Epub 2019 Dec 17. Angew Chem Int Ed Engl. 2020. PMID: 31724281
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