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Progress in Free Energy Perturbation: Options for Evolving Fragments.
Zara L, Efrém NL, van Muijlwijk-Koezen JE, de Esch IJP, Zarzycka B. Zara L, et al. Among authors: van muijlwijk koezen je. Drug Discov Today Technol. 2021 Dec;40:36-42. doi: 10.1016/j.ddtec.2021.10.001. Epub 2021 Nov 18. Drug Discov Today Technol. 2021. PMID: 34916020 Review.
Surface plasmon resonance biosensor based fragment screening using acetylcholine binding protein identifies ligand efficiency hot spots (LE hot spots) by deconstruction of nicotinic acetylcholine receptor α7 ligands.
de Kloe GE, Retra K, Geitmann M, Källblad P, Nahar T, van Elk R, Smit AB, van Muijlwijk-Koezen JE, Leurs R, Irth H, Danielson UH, de Esch IJ. de Kloe GE, et al. J Med Chem. 2010 Oct 14;53(19):7192-201. doi: 10.1021/jm100834y. J Med Chem. 2010. PMID: 20828128
Fragment library screening reveals remarkable similarities between the G protein-coupled receptor histamine H₄ and the ion channel serotonin 5-HT₃A.
Verheij MH, de Graaf C, de Kloe GE, Nijmeijer S, Vischer HF, Smits RA, Zuiderveld OP, Hulscher S, Silvestri L, Thompson AJ, van Muijlwijk-Koezen JE, Lummis SC, Leurs R, de Esch IJ. Verheij MH, et al. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5460-4. doi: 10.1016/j.bmcl.2011.06.123. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21782429 Free PMC article.
Career development in fragment-based drug discovery.
Romasanta AKS, van der Sijde PC, Smit MJ, de Esch IJP, Jahnke W, van Muijlwijk-Koezen JE. Romasanta AKS, et al. Among authors: van muijlwijk koezen je. Drug Discov Today Technol. 2020 Dec;37:107-116. doi: 10.1016/j.ddtec.2020.10.001. Epub 2020 Dec 1. Drug Discov Today Technol. 2020. PMID: 34895649 Free article. Review.
Discovery of fragments inducing conformational effects in dynamic proteins using a second-harmonic generation biosensor.
FitzGerald EA, Butko MT, Boronat P, Cederfelt D, Abramsson M, Ludviksdottir H, van Muijlwijk-Koezen JE, de Esch IJP, Dobritzsch D, Young T, Danielson UH. FitzGerald EA, et al. Among authors: van muijlwijk koezen je. RSC Adv. 2021 Feb 17;11(13):7527-7537. doi: 10.1039/d0ra09844b. eCollection 2021 Feb 10. RSC Adv. 2021. PMID: 35423271 Free PMC article.
Small and colorful stones make beautiful mosaics: fragment-based chemogenomics.
de Graaf C, Vischer HF, de Kloe GE, Kooistra AJ, Nijmeijer S, Kuijer M, Verheij MH, England PJ, van Muijlwijk-Koezen JE, Leurs R, de Esch IJ. de Graaf C, et al. Among authors: van muijlwijk koezen je. Drug Discov Today. 2013 Apr;18(7-8):323-30. doi: 10.1016/j.drudis.2012.12.003. Epub 2012 Dec 22. Drug Discov Today. 2013. PMID: 23266367
24 results