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Functional divergence of the two Elongator subcomplexes during neurodevelopment.
Gaik M, Kojic M, Stegeman MR, Öncü-Öner T, Kościelniak A, Jones A, Mohamed A, Chau PYS, Sharmin S, Chramiec-Głąbik A, Indyka P, Rawski M, Biela A, Dobosz D, Millar A, Chau V, Ünalp A, Piper M, Bellingham MC, Eichler EE, Nickerson DA, Güleryüz H, Abbassi NEH, Jazgar K, Davis MJ, Mercimek-Andrews S, Cingöz S, Wainwright BJ, Glatt S. Gaik M, et al. Among authors: wainwright bj. EMBO Mol Med. 2022 Jul 7;14(7):e15608. doi: 10.15252/emmm.202115608. Epub 2022 Jun 13. EMBO Mol Med. 2022. PMID: 35698786 Free PMC article.
Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.
Genovesi LA, Ng CG, Davis MJ, Remke M, Taylor MD, Adams DJ, Rust AG, Ward JM, Ban KH, Jenkins NA, Copeland NG, Wainwright BJ. Genovesi LA, et al. Among authors: wainwright bj. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):E4325-34. doi: 10.1073/pnas.1318639110. Epub 2013 Oct 28. Proc Natl Acad Sci U S A. 2013. PMID: 24167280 Free PMC article.
Elongator mutation in mice induces neurodegeneration and ataxia-like behavior.
Kojic M, Gaik M, Kiska B, Salerno-Kochan A, Hunt S, Tedoldi A, Mureev S, Jones A, Whittle B, Genovesi LA, Adolphe C, Brown DL, Stow JL, Alexandrov K, Sah P, Glatt S, Wainwright BJ. Kojic M, et al. Among authors: wainwright bj. Nat Commun. 2018 Aug 10;9(1):3195. doi: 10.1038/s41467-018-05765-6. Nat Commun. 2018. PMID: 30097576 Free PMC article.
Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype.
Kojic M, Gawda T, Gaik M, Begg A, Salerno-Kochan A, Kurniawan ND, Jones A, Drożdżyk K, Kościelniak A, Chramiec-Głąbik A, Hediyeh-Zadeh S, Kasherman M, Shim WJ, Sinniah E, Genovesi LA, Abrahamsen RK, Fenger CD, Madsen CG, Cohen JS, Fatemi A, Stark Z, Lunke S, Lee J, Hansen JK, Boxill MF, Keren B, Marey I, Saenz MS, Brown K, Alexander SA, Mureev S, Batzilla A, Davis MJ, Piper M, Bodén M, Burne THJ, Palpant NJ, Møller RS, Glatt S, Wainwright BJ. Kojic M, et al. Among authors: wainwright bj. Nat Commun. 2021 May 11;12(1):2678. doi: 10.1038/s41467-021-22888-5. Nat Commun. 2021. PMID: 33976153 Free PMC article.
Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma.
Genovesi LA, Millar A, Tolson E, Singleton M, Hassall E, Kojic M, Brighi C, Girard E, Andradas C, Kuchibhotla M, Bhuva DD, Endersby R, Gottardo NG, Bernard A, Adolphe C, Olson JM, Taylor MD, Davis MJ, Wainwright BJ. Genovesi LA, et al. Among authors: wainwright bj. Genome Med. 2021 Jun 21;13(1):103. doi: 10.1186/s13073-021-00920-z. Genome Med. 2021. PMID: 34154646 Free PMC article.
198 results