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Page 1
Conditionally immortalized brown preadipocytes can switch between proliferative and differentiated states.
Liu J, Kuipers EN, Sips HCM, Dorleijn JC, van Dam AD, Christodoulides C, Karpe F, Zhou G, Boon MR, Rensen PCN, de Vries AAF, Kooijman S. Liu J, et al. Among authors: van dam ad. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Dec;1864(12):158511. doi: 10.1016/j.bbalip.2019.08.007. Epub 2019 Aug 26. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31465889 Free article.
HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution.
Kuo FC, Neville MJ, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans LBL, van Dam AD, Loh NY, Todorčević M, Denton N, Kentistou KA, Joshi PK, Christodoulides C, Langenberg C, Collas P, Karpe F, Pinnick KE. Kuo FC, et al. Among authors: van dam ad. Cell Rep. 2022 Jul 26;40(4):111136. doi: 10.1016/j.celrep.2022.111136. Cell Rep. 2022. PMID: 35905723 Free PMC article.
Higher Plasma Sclerostin and Lower Wnt Signaling Gene Expression in White Adipose Tissue of Prediabetic South Asian Men Compared with White Caucasian Men.
Janssen LGM, Van Dam AD, Hanssen MJW, Kooijman S, Nahon KJ, Reinders H, Jazet IM, Van Marken Lichtenbelt WD, Rensen PCN, Appelman-Dijkstra NM, Boon MR. Janssen LGM, et al. Among authors: van dam ad. Diabetes Metab J. 2020 Apr;44(2):326-335. doi: 10.4093/dmj.2019.0031. Epub 2019 Oct 31. Diabetes Metab J. 2020. PMID: 31701693 Free PMC article. Clinical Trial.
Immune Modulation of Brown(ing) Adipose Tissue in Obesity.
van den Berg SM, van Dam AD, Rensen PC, de Winther MP, Lutgens E. van den Berg SM, et al. Among authors: van dam ad. Endocr Rev. 2017 Feb 1;38(1):46-68. doi: 10.1210/er.2016-1066. Endocr Rev. 2017. PMID: 27849358 Review.
Salsalate activates brown adipose tissue in mice.
van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombès M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR. van Dam AD, et al. Among authors: van harmelen v, van den hoek am, van den berg sm. Diabetes. 2015 May;64(5):1544-54. doi: 10.2337/db14-1125. Epub 2014 Dec 4. Diabetes. 2015. PMID: 25475439
The GPR120 agonist TUG-891 promotes metabolic health by stimulating mitochondrial respiration in brown fat.
Schilperoort M, van Dam AD, Hoeke G, Shabalina IG, Okolo A, Hanyaloglu AC, Dib LH, Mol IM, Caengprasath N, Chan YW, Damak S, Miller AR, Coskun T, Shimpukade B, Ulven T, Kooijman S, Rensen PC, Christian M. Schilperoort M, et al. Among authors: van dam ad. EMBO Mol Med. 2018 Mar;10(3):e8047. doi: 10.15252/emmm.201708047. EMBO Mol Med. 2018. PMID: 29343498 Free PMC article.
IgG is elevated in obese white adipose tissue but does not induce glucose intolerance via Fcγ-receptor or complement.
van Dam AD, van Beek L, Pronk ACM, van den Berg SM, Van den Bossche J, de Winther MPJ, Koning F, van Kooten C, Rensen PCN, Boon MR, Verbeek JS, van Dijk KW, van Harmelen V. van Dam AD, et al. Among authors: van harmelen v, van den bossche j, van kooten c, van dijk kw, van beek l, van den berg sm. Int J Obes (Lond). 2018 Feb;42(2):260-269. doi: 10.1038/ijo.2017.209. Epub 2017 Aug 30. Int J Obes (Lond). 2018. PMID: 28852207
OxPhos in adipose tissue macrophages regulated by BTK enhances their M2-like phenotype and confers a systemic immunometabolic benefit in obesity.
Purvis GSD, Collino M, van Dam AD, Einaudi G, Ng Y, Shanmuganathan M, Patel SY, Thiemermann C, Channon KM, Greaves DR; Oxford Acute Myocardial Infarction (OxAMI) Study. Purvis GSD, et al. Among authors: van dam ad. Diabetes. 2024 Jan 8:db220275. doi: 10.2337/db22-0275. Online ahead of print. Diabetes. 2024. PMID: 38193882
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