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Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition.
Small KS, Todorčević M, Civelek M, El-Sayed Moustafa JS, Wang X, Simon MM, Fernandez-Tajes J, Mahajan A, Horikoshi M, Hugill A, Glastonbury CA, Quaye L, Neville MJ, Sethi S, Yon M, Pan C, Che N, Viñuela A, Tsai PC, Nag A, Buil A, Thorleifsson G, Raghavan A, Ding Q, Morris AP, Bell JT, Thorsteinsdottir U, Stefansson K, Laakso M, Dahlman I, Arner P, Gloyn AL, Musunuru K, Lusis AJ, Cox RD, Karpe F, McCarthy MI. Small KS, et al. Among authors: todorcevic m. Nat Genet. 2018 Apr;50(4):572-580. doi: 10.1038/s41588-018-0088-x. Epub 2018 Apr 9. Nat Genet. 2018. PMID: 29632379 Free PMC article.
Regional fat depot masses are influenced by protein-coding gene variants.
Neville MJ, Wittemans LBL, Pinnick KE, Todorčević M, Kaksonen R, Pietiläinen KH, Luan J, Scott RA, Wareham NJ, Langenberg C, Karpe F. Neville MJ, et al. Among authors: todorcevic m. PLoS One. 2019 May 30;14(5):e0217644. doi: 10.1371/journal.pone.0217644. eCollection 2019. PLoS One. 2019. PMID: 31145760 Free PMC article.
Bone morphogenetic protein 2 is a depot-specific regulator of human adipogenesis.
Denton NF, Eghleilib M, Al-Sharifi S, Todorčević M, Neville MJ, Loh N, Drakesmith A, Karpe F, Pinnick KE. Denton NF, et al. Among authors: todorcevic m. Int J Obes (Lond). 2019 Dec;43(12):2458-2468. doi: 10.1038/s41366-019-0421-1. Epub 2019 Jul 19. Int J Obes (Lond). 2019. PMID: 31324879 Free PMC article.
RSPO3 impacts body fat distribution and regulates adipose cell biology in vitro.
Loh NY, Minchin JEN, Pinnick KE, Verma M, Todorčević M, Denton N, Moustafa JE, Kemp JP, Gregson CL, Evans DM, Neville MJ, Small KS, McCarthy MI, Mahajan A, Rawls JF, Karpe F, Christodoulides C. Loh NY, et al. Among authors: todorcevic m. Nat Commun. 2020 Jun 3;11(1):2797. doi: 10.1038/s41467-020-16592-z. Nat Commun. 2020. PMID: 32493999 Free PMC article.
34 results