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A metal ion-dependent conformational switch modulates activity of the Plasmodium M17 aminopeptidase.
J Biol Chem. 2022 Jul;298(7):102119. doi: 10.1016/j.jbc.2022.102119. Epub 2022 Jun 9.
J Biol Chem. 2022.
PMID: 35691342
Free PMC article.
X-ray crystal structures of an orally available aminopeptidase inhibitor, Tosedostat, bound to anti-malarial drug targets PfA-M1 and PfA-M17.
Drinkwater N, Bamert RS, Sivaraman KK, Paiardini A, McGowan S.
Drinkwater N, et al. Among authors: sivaraman kk.
Proteins. 2015 Apr;83(4):789-95. doi: 10.1002/prot.24771. Epub 2015 Feb 28.
Proteins. 2015.
PMID: 25645579
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X-ray crystal structure and specificity of the Plasmodium falciparum malaria aminopeptidase PfM18AAP.
Sivaraman KK, Oellig CA, Huynh K, Atkinson SC, Poreba M, Perugini MA, Trenholme KR, Gardiner DL, Salvesen G, Drag M, Dalton JP, Whisstock JC, McGowan S.
Sivaraman KK, et al.
J Mol Biol. 2012 Sep 28;422(4):495-507. doi: 10.1016/j.jmb.2012.06.006. Epub 2012 Jun 16.
J Mol Biol. 2012.
PMID: 22709581
Free article.
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Two-pronged attack: dual inhibition of Plasmodium falciparum M1 and M17 metalloaminopeptidases by a novel series of hydroxamic acid-based inhibitors.
Mistry SN, Drinkwater N, Ruggeri C, Sivaraman KK, Loganathan S, Fletcher S, Drag M, Paiardini A, Avery VM, Scammells PJ, McGowan S.
Mistry SN, et al. Among authors: sivaraman kk.
J Med Chem. 2014 Nov 13;57(21):9168-83. doi: 10.1021/jm501323a. Epub 2014 Oct 24.
J Med Chem. 2014.
PMID: 25299353
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Identification and Validation of a Potent Dual Inhibitor of the P. falciparum M1 and M17 Aminopeptidases Using Virtual Screening.
Ruggeri C, Drinkwater N, Sivaraman KK, Bamert RS, McGowan S, Paiardini A.
Ruggeri C, et al. Among authors: sivaraman kk.
PLoS One. 2015 Sep 25;10(9):e0138957. doi: 10.1371/journal.pone.0138957. eCollection 2015.
PLoS One. 2015.
PMID: 26406322
Free PMC article.
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Structure and substrate fingerprint of aminopeptidase P from Plasmodium falciparum.
Drinkwater N, Sivaraman KK, Bamert RS, Rut W, Mohamed K, Vinh NB, Scammells PJ, Drag M, McGowan S.
Drinkwater N, et al. Among authors: sivaraman kk.
Biochem J. 2016 Oct 1;473(19):3189-204. doi: 10.1042/BCJ20160550. Epub 2016 Jul 26.
Biochem J. 2016.
PMID: 27462122
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Toxoplasma gondii Toxolysin 4 Contributes to Efficient Parasite Egress from Host Cells.
Huynh MH, Roiko MS, Gomes AO, Schinke EN, Schultz AJ, Agrawal S, Oellig CA, Sexton TR, Beauchamp JM, Laliberté J, Sivaraman KK, Hersh LB, McGowan S, Carruthers VB.
Huynh MH, et al. Among authors: sivaraman kk.
mSphere. 2021 Jun 30;6(3):e0044421. doi: 10.1128/mSphere.00444-21. Online ahead of print.
mSphere. 2021.
PMID: 34190588
Free PMC article.
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The molecular assembly of the marsupial γμ T cell receptor defines a third T cell lineage.
Morrissey KA, Wegrecki M, Praveena T, Hansen VL, Bu L, Sivaraman KK, Darko S, Douek DC, Rossjohn J, Miller RD, Le Nours J.
Morrissey KA, et al. Among authors: sivaraman kk.
Science. 2021 Mar 26;371(6536):1383-1388. doi: 10.1126/science.abe7070.
Science. 2021.
PMID: 33766885
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