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Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.
Biochem Pharmacol. 2022 Aug;202:115123. doi: 10.1016/j.bcp.2022.115123. Epub 2022 Jun 8.
Biochem Pharmacol. 2022.
PMID: 35688178
Asymmetric Total Synthesis and Biological Evaluation of the Natural PDE4 Inhibitor Toddacoumalone.
Hou KQ, Chen XP, Huang Y, Chan ASC, Luo HB, Xiong XF.
Hou KQ, et al.
Org Lett. 2020 Jan 17;22(2):584-588. doi: 10.1021/acs.orglett.9b04355. Epub 2020 Jan 6.
Org Lett. 2020.
PMID: 31904969
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Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
Song Z, Huang YY, Hou KQ, Liu L, Zhou F, Huang Y, Wan G, Luo HB, Xiong XF.
Song Z, et al. Among authors: hou kq.
J Med Chem. 2022 Mar 10;65(5):4238-4254. doi: 10.1021/acs.jmedchem.1c02058. Epub 2022 Feb 21.
J Med Chem. 2022.
PMID: 35188767
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Organocatalytic Asymmetric Synthesis of Benzothiazolopyrimidines via [4 + 2] Cyclization of 2-Benzothiazolimines and Aldehydes.
Chen XP, Hou KQ, Zhou F, Chan ASC, Xiong XF.
Chen XP, et al. Among authors: hou kq.
J Org Chem. 2021 Jan 15;86(2):1667-1675. doi: 10.1021/acs.joc.0c02499. Epub 2021 Jan 6.
J Org Chem. 2021.
PMID: 33406829
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Asymmetric Synthesis of Oxindole-Derived Vicinal Tetrasubstituted Acyclic Amino Acid Derivatives by the Mannich-Type Reaction.
Hou KQ, Zhou F, Chen XP, Ge Y, Chan ASC, Xiong XF.
Hou KQ, et al.
J Org Chem. 2020 Aug 7;85(15):9661-9671. doi: 10.1021/acs.joc.0c00981. Epub 2020 Jul 10.
J Org Chem. 2020.
PMID: 32603113
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Construction of α,β-Diamino Diacid Derivatives with Adjacent Acyclic Tetrasubstituted Stereocenters.
Zhou F, Hu QL, Hou KQ, Chan ASC, Xiong XF.
Zhou F, et al. Among authors: hou kq.
J Org Chem. 2022 Jul 1;87(13):8709-8718. doi: 10.1021/acs.joc.2c00950. Epub 2022 Jun 17.
J Org Chem. 2022.
PMID: 35713885
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Silanol: a bifunctional group for peptide synthesis and late-stage functionalization.
Hu QL, Hou KQ, Li J, Ge Y, Song ZD, Chan ASC, Xiong XF.
Hu QL, et al. Among authors: hou kq.
Chem Sci. 2020 Jun 3;11(23):6070-6074. doi: 10.1039/d0sc02439b.
Chem Sci. 2020.
PMID: 34094099
Free PMC article.
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Organocatalytic Asymmetric Three-Component Povarov Reactions of Anilines and Aldehydes.
Huang JX, Hou KQ, Hu QL, Chen XP, Li J, Chan ASC, Xiong XF.
Huang JX, et al. Among authors: hou kq.
Org Lett. 2020 Mar 6;22(5):1858-1862. doi: 10.1021/acs.orglett.0c00206. Epub 2020 Feb 21.
Org Lett. 2020.
PMID: 32083880
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