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Activation of the ghrelin receptor is described by a privileged collective motion: a model for constitutive and agonist-induced activation of a sub-class A G-protein coupled receptor (GPCR).
Floquet N, M'Kadmi C, Perahia D, Gagne D, Bergé G, Marie J, Banères JL, Galleyrand JC, Fehrentz JA, Martinez J. Floquet N, et al. Among authors: fehrentz ja. J Mol Biol. 2010 Jan 29;395(4):769-84. doi: 10.1016/j.jmb.2009.09.051. Epub 2009 Sep 25. J Mol Biol. 2010. PMID: 19782690
Homogeneous time-resolved fluorescence-based assay to screen for ligands targeting the growth hormone secretagogue receptor type 1a.
Leyris JP, Roux T, Trinquet E, Verdié P, Fehrentz JA, Oueslati N, Douzon S, Bourrier E, Lamarque L, Gagne D, Galleyrand JC, M'kadmi C, Martinez J, Mary S, Banères JL, Marie J. Leyris JP, et al. Among authors: fehrentz ja. Anal Biochem. 2011 Jan 15;408(2):253-62. doi: 10.1016/j.ab.2010.09.030. Epub 2010 Sep 24. Anal Biochem. 2011. PMID: 20937574
Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons.
Schaeffer M, Langlet F, Lafont C, Molino F, Hodson DJ, Roux T, Lamarque L, Verdié P, Bourrier E, Dehouck B, Banères JL, Martinez J, Méry PF, Marie J, Trinquet E, Fehrentz JA, Prévot V, Mollard P. Schaeffer M, et al. Among authors: fehrentz ja. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1512-7. doi: 10.1073/pnas.1212137110. Epub 2013 Jan 7. Proc Natl Acad Sci U S A. 2013. PMID: 23297228 Free PMC article.
Heterodimerization with Its splice variant blocks the ghrelin receptor 1a in a non-signaling conformation: a study with a purified heterodimer assembled into lipid discs.
Mary S, Fehrentz JA, Damian M, Gaibelet G, Orcel H, Verdié P, Mouillac B, Martinez J, Marie J, Banères JL. Mary S, et al. Among authors: fehrentz ja. J Biol Chem. 2013 Aug 23;288(34):24656-65. doi: 10.1074/jbc.M113.453423. Epub 2013 Jul 9. J Biol Chem. 2013. PMID: 23839942 Free PMC article.
Ghrelin receptor conformational dynamics regulate the transition from a preassembled to an active receptor:Gq complex.
Damian M, Mary S, Maingot M, M'Kadmi C, Gagne D, Leyris JP, Denoyelle S, Gaibelet G, Gavara L, Garcia de Souza Costa M, Perahia D, Trinquet E, Mouillac B, Galandrin S, Galès C, Fehrentz JA, Floquet N, Martinez J, Marie J, Banères JL. Damian M, et al. Among authors: fehrentz ja. Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1601-6. doi: 10.1073/pnas.1414618112. Epub 2015 Jan 20. Proc Natl Acad Sci U S A. 2015. PMID: 25605885 Free PMC article.
Agonism, Antagonism, and Inverse Agonism Bias at the Ghrelin Receptor Signaling.
M'Kadmi C, Leyris JP, Onfroy L, Galés C, Saulière A, Gagne D, Damian M, Mary S, Maingot M, Denoyelle S, Verdié P, Fehrentz JA, Martinez J, Banères JL, Marie J. M'Kadmi C, et al. Among authors: fehrentz ja. J Biol Chem. 2015 Nov 6;290(45):27021-27039. doi: 10.1074/jbc.M115.659250. Epub 2015 Sep 11. J Biol Chem. 2015. PMID: 26363071 Free PMC article.
136 results