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Highly infectious prions are not directly neurotoxic.
Benilova I, Reilly M, Terry C, Wenborn A, Schmidt C, Marinho AT, Risse E, Al-Doujaily H, Wiggins De Oliveira M, Sandberg MK, Wadsworth JDF, Jat PS, Collinge J. Benilova I, et al. Proc Natl Acad Sci U S A. 2020 Sep 22;117(38):23815-23822. doi: 10.1073/pnas.2007406117. Epub 2020 Sep 8. Proc Natl Acad Sci U S A. 2020. PMID: 32900920 Free PMC article.
Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium.
Nahass GR, Sun Y, Xu Y, Batchelor M, Reilly M, Benilova I, Kedia N, Spehar K, Sobott F, Sessions RB, Caughey B, Radford SE, Jat PS, Collinge J, Bieschke J. Nahass GR, et al. Among authors: benilova i. J Mol Biol. 2021 Apr 16;433(8):166878. doi: 10.1016/j.jmb.2021.166878. Epub 2021 Feb 19. J Mol Biol. 2021. PMID: 33610557 Free PMC article.
Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio.
Kuperstein I, Broersen K, Benilova I, Rozenski J, Jonckheere W, Debulpaep M, Vandersteen A, Segers-Nolten I, Van Der Werf K, Subramaniam V, Braeken D, Callewaert G, Bartic C, D'Hooge R, Martins IC, Rousseau F, Schymkowitz J, De Strooper B. Kuperstein I, et al. Among authors: benilova i. EMBO J. 2010 Oct 6;29(19):3408-20. doi: 10.1038/emboj.2010.211. Epub 2010 Sep 3. EMBO J. 2010. PMID: 20818335 Free PMC article.
22 results