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Nuclear Export Inhibition for Radiosensitization: A Proof-of-Concept Phase 1 Clinical Trial of Selinexor (KPT-330) Combined With Neoadjuvant Chemoradiation in Locally Advanced Rectal Cancer.
Lawrence YR, Shacham-Shmueli E, Yarom N, Khaikin M, Venturero M, Apter S, Inbar Y, Symon Z, Aderka D, Halpern N, Berger R, Boursi B, Jacobson G, Raskin S, Ackerstein A, Margalit O, Appel S, Schvimer M, Crochiere M, Yang F, Landesman Y, Rashal T, Shacham S, Golan T. Lawrence YR, et al. Among authors: landesman y. Int J Radiat Oncol Biol Phys. 2022 Oct 1;114(2):250-255. doi: 10.1016/j.ijrobp.2022.05.026. Epub 2022 Jun 3. Int J Radiat Oncol Biol Phys. 2022. PMID: 35667526 Clinical Trial. No abstract available.
Clinical translation of nuclear export inhibitors in cancer.
Senapedis WT, Baloglu E, Landesman Y. Senapedis WT, et al. Among authors: landesman y. Semin Cancer Biol. 2014 Aug;27:74-86. doi: 10.1016/j.semcancer.2014.04.005. Epub 2014 Apr 19. Semin Cancer Biol. 2014. PMID: 24755012 Review.
XPO1/CRM1-selective inhibitors of nuclear export (SINE) reduce tumor spreading and improve overall survival in preclinical models of prostate cancer (PCa).
Gravina GL, Tortoreto M, Mancini A, Addis A, Di Cesare E, Lenzi A, Landesman Y, McCauley D, Kauffman M, Shacham S, Zaffaroni N, Festuccia C. Gravina GL, et al. Among authors: landesman y. J Hematol Oncol. 2014 Oct 5;7:46. doi: 10.1186/1756-8722-7-46. J Hematol Oncol. 2014. PMID: 25284315 Free PMC article.
Anti-tumor activity of selective inhibitors of XPO1/CRM1-mediated nuclear export in diffuse malignant peritoneal mesothelioma: the role of survivin.
De Cesare M, Cominetti D, Doldi V, Lopergolo A, Deraco M, Gandellini P, Friedlander S, Landesman Y, Kauffman MG, Shacham S, Pennati M, Zaffaroni N. De Cesare M, et al. Among authors: landesman y. Oncotarget. 2015 May 30;6(15):13119-32. doi: 10.18632/oncotarget.3761. Oncotarget. 2015. PMID: 25948791 Free PMC article.
121 results