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Nonclinical Efficacy and Safety of CX-2029, an Anti-CD71 Probody-Drug Conjugate.
Singh S, Serwer L, DuPage A, Elkins K, Chauhan N, Ravn M, Buchanan F, Wang L, Krimm M, Wong K, Sagert J, Tipton K, Moore SJ, Huang Y, Jang A, Ureno E, Miller A, Patrick S, Duvur S, Liu S, Vasiljeva O, Li Y, Henriques T, Badagnani I, Jeffries S, Schleyer S, Leanna R, Krebber C, Viswanathan S, Desnoyers L, Terrett J, Belvin M, Morgan-Lappe S, Kavanaugh WM, Richardson J. Singh S, et al. Among authors: desnoyers l. Mol Cancer Ther. 2022 Aug 2;21(8):1326-1336. doi: 10.1158/1535-7163.MCT-21-0193. Mol Cancer Ther. 2022. PMID: 35666803 Free PMC article.
Tumor-specific activation of an EGFR-targeting probody enhances therapeutic index.
Desnoyers LR, Vasiljeva O, Richardson JH, Yang A, Menendez EE, Liang TW, Wong C, Bessette PH, Kamath K, Moore SJ, Sagert JG, Hostetter DR, Han F, Gee J, Flandez J, Markham K, Nguyen M, Krimm M, Wong KR, Liu S, Daugherty PS, West JW, Lowman HB. Desnoyers LR, et al. Sci Transl Med. 2013 Oct 16;5(207):207ra144. doi: 10.1126/scitranslmed.3006682. Sci Transl Med. 2013. PMID: 24132639
Model-Informed Drug Development of the Masked Anti-PD-L1 Antibody CX-072.
Stroh M, Green M, Millard BL, Apgar JF, Burke JM, Garner W, Lu H, Lyman SK, Desnoyers LR, Richardson J, Hannah A, Kavanaugh WM. Stroh M, et al. Among authors: desnoyers lr. Clin Pharmacol Ther. 2021 Feb;109(2):383-393. doi: 10.1002/cpt.1985. Epub 2020 Aug 31. Clin Pharmacol Ther. 2021. PMID: 32681519
Targeting FGFR4 inhibits hepatocellular carcinoma in preclinical mouse models.
French DM, Lin BC, Wang M, Adams C, Shek T, Hötzel K, Bolon B, Ferrando R, Blackmore C, Schroeder K, Rodriguez LA, Hristopoulos M, Venook R, Ashkenazi A, Desnoyers LR. French DM, et al. Among authors: desnoyers lr. PLoS One. 2012;7(5):e36713. doi: 10.1371/journal.pone.0036713. Epub 2012 May 15. PLoS One. 2012. PMID: 22615798 Free PMC article.
FGF19 and cancer.
Lin BC, Desnoyers LR. Lin BC, et al. Among authors: desnoyers lr. Adv Exp Med Biol. 2012;728:183-94. doi: 10.1007/978-1-4614-0887-1_12. Adv Exp Med Biol. 2012. PMID: 22396170 Review.
Liver-specific activities of FGF19 require Klotho beta.
Lin BC, Wang M, Blackmore C, Desnoyers LR. Lin BC, et al. Among authors: desnoyers lr. J Biol Chem. 2007 Sep 14;282(37):27277-27284. doi: 10.1074/jbc.M704244200. Epub 2007 Jul 11. J Biol Chem. 2007. PMID: 17627937 Free article.
WISP-1 binds to decorin and biglycan.
Desnoyers L, Arnott D, Pennica D. Desnoyers L, et al. J Biol Chem. 2001 Dec 14;276(50):47599-607. doi: 10.1074/jbc.M108339200. Epub 2001 Oct 11. J Biol Chem. 2001. PMID: 11598131 Free article.
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