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An Engineered Cytidine Deaminase for Biocatalytic Production of a Key Intermediate of the Covid-19 Antiviral Molnupiravir.
Burke AJ, Birmingham WR, Zhuo Y, Thorpe TW, Zucoloto da Costa B, Crawshaw R, Rowles I, Finnigan JD, Young C, Holgate GM, Muldowney MP, Charnock SJ, Lovelock SL, Turner NJ, Green AP. Burke AJ, et al. Among authors: thorpe tw. J Am Chem Soc. 2022 Mar 9;144(9):3761-3765. doi: 10.1021/jacs.1c11048. Epub 2022 Feb 28. J Am Chem Soc. 2022. PMID: 35224970 Free PMC article.
Multifunctional biocatalyst for conjugate reduction and reductive amination.
Thorpe TW, Marshall JR, Harawa V, Ruscoe RE, Cuetos A, Finnigan JD, Angelastro A, Heath RS, Parmeggiani F, Charnock SJ, Howard RM, Kumar R, Daniels DSB, Grogan G, Turner NJ. Thorpe TW, et al. Nature. 2022 Apr;604(7904):86-91. doi: 10.1038/s41586-022-04458-x. Epub 2022 Apr 6. Nature. 2022. PMID: 35388195
A Reductive Aminase Switches to Imine Reductase Mode for a Bulky Amine Substrate.
Gilio AK, Thorpe TW, Heyam A, Petchey MR, Pogrányi B, France SP, Howard RM, Karmilowicz MJ, Lewis R, Turner N, Grogan G. Gilio AK, et al. Among authors: thorpe tw. ACS Catal. 2023 Jan 12;13(3):1669-1677. doi: 10.1021/acscatal.2c06066. eCollection 2023 Feb 3. ACS Catal. 2023. PMID: 36776386 Free PMC article.
RetroBioCat Database: A Platform for Collaborative Curation and Automated Meta-Analysis of Biocatalysis Data.
Finnigan W, Lubberink M, Hepworth LJ, Citoler J, Mattey AP, Ford GJ, Sangster J, Cosgrove SC, da Costa BZ, Heath RS, Thorpe TW, Yu Y, Flitsch SL, Turner NJ. Finnigan W, et al. Among authors: thorpe tw. ACS Catal. 2023 Aug 22;13(17):11771-11780. doi: 10.1021/acscatal.3c01418. eCollection 2023 Sep 1. ACS Catal. 2023. PMID: 37671181 Free PMC article.
Multifunctional Biocatalysts for Organic Synthesis.
Thorpe TW, Marshall JR, Turner NJ. Thorpe TW, et al. J Am Chem Soc. 2024 Mar 27;146(12):7876-7884. doi: 10.1021/jacs.3c09542. Epub 2024 Mar 15. J Am Chem Soc. 2024. PMID: 38489244 Free PMC article. Review.
11 results