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Citraconate inhibits ACOD1 (IRG1) catalysis, reduces interferon responses and oxidative stress, and modulates inflammation and cell metabolism.
Chen F, Elgaher WAM, Winterhoff M, Büssow K, Waqas FH, Graner E, Pires-Afonso Y, Casares Perez L, de la Vega L, Sahini N, Czichon L, Zobl W, Zillinger T, Shehata M, Pleschka S, Bähre H, Falk C, Michelucci A, Schuchardt S, Blankenfeldt W, Hirsch AKH, Pessler F. Chen F, et al. Among authors: graner e. Nat Metab. 2022 May;4(5):534-546. doi: 10.1038/s42255-022-00577-x. Epub 2022 Jun 2. Nat Metab. 2022. PMID: 35655026 Free PMC article.
A Reductionist Approach Using Primary and Metastatic Cell-Derived Extracellular Vesicles Reveals Hub Proteins Associated with Oral Cancer Prognosis.
Busso-Lopes AF, Carnielli CM, Winck FV, Patroni FMS, Oliveira AK, Granato DC, E Costa RAP, Domingues RR, Pauletti BA, Riaño-Pachón DM, Aricetti J, Caldana C, Graner E, Coletta RD, Dryden K, Fox JW, Paes Leme AF. Busso-Lopes AF, et al. Among authors: graner e. Mol Cell Proteomics. 2021;20:100118. doi: 10.1016/j.mcpro.2021.100118. Epub 2021 Jun 27. Mol Cell Proteomics. 2021. PMID: 34186243 Free PMC article.
Stanniocalcin 2 contributes to aggressiveness and is a prognostic marker for oral squamous cell carcinoma.
Ferreira do Carmo A, Dourado MR, Ervolino de Oliveira C, Bastos DC, Domingueti CB, Ribeiro Paranaíba LM, Sawazaki-Calone Í, Borges GÁ, Silva Guerra EN, Casarin RC, Graner E, Salo TA, de Almeida Freitas R, Galvão HC, Coletta RD. Ferreira do Carmo A, et al. Among authors: graner e. Exp Cell Res. 2020 Aug 15;393(2):112092. doi: 10.1016/j.yexcr.2020.112092. Epub 2020 May 20. Exp Cell Res. 2020. PMID: 32445747
Activin A triggers angiogenesis via regulation of VEGFA and its overexpression is associated with poor prognosis of oral squamous cell carcinoma.
Ervolino De Oliveira C, Dourado MR, Sawazaki-Calone Í, Costa De Medeiros M, Rossa Júnior C, De Karla Cervigne N, Esquiche León J, Lambert D, Salo T, Graner E, Coletta RD. Ervolino De Oliveira C, et al. Among authors: graner e. Int J Oncol. 2020 Jul;57(1):364-376. doi: 10.3892/ijo.2020.5058. Epub 2020 May 4. Int J Oncol. 2020. PMID: 32377747
119 results