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Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin.
Palchaudhuri R, Saez B, Hoggatt J, Schajnovitz A, Sykes DB, Tate TA, Czechowicz A, Kfoury Y, Ruchika F, Rossi DJ, Verdine GL, Mansour MK, Scadden DT. Palchaudhuri R, et al. Among authors: sykes db. Nat Biotechnol. 2016 Jul;34(7):738-45. doi: 10.1038/nbt.3584. Epub 2016 Jun 6. Nat Biotechnol. 2016. PMID: 27272386 Free PMC article.
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity.
Cabal-Hierro L, van Galen P, Prado MA, Higby KJ, Togami K, Mowery CT, Paulo JA, Xie Y, Cejas P, Furusawa T, Bustin M, Long HW, Sykes DB, Gygi SP, Finley D, Bernstein BE, Lane AA. Cabal-Hierro L, et al. Among authors: sykes db. Nat Commun. 2020 Mar 16;11(1):1406. doi: 10.1038/s41467-020-15221-z. Nat Commun. 2020. PMID: 32179749 Free PMC article.
Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses.
Hirz T, Mei S, Sarkar H, Kfoury Y, Wu S, Verhoeven BM, Subtelny AO, Zlatev DV, Wszolek MW, Salari K, Murray E, Chen F, Macosko EZ, Wu CL, Scadden DT, Dahl DM, Baryawno N, Saylor PJ, Kharchenko PV, Sykes DB. Hirz T, et al. Among authors: sykes db. Nat Commun. 2023 Feb 7;14(1):663. doi: 10.1038/s41467-023-36325-2. Nat Commun. 2023. PMID: 36750562 Free PMC article.
Prenylcysteine oxidase 1 like protein is required for neutrophil bactericidal activities.
Petenkova A, Auger SA, Lamb J, Quellier D, Carter C, To OT, Milosevic J, Barghout R, Kugadas A, Lu X, Geddes-McAlister J, Fichorova R, Sykes DB, Distefano MD, Gadjeva M. Petenkova A, et al. Among authors: sykes db. Nat Commun. 2023 May 13;14(1):2761. doi: 10.1038/s41467-023-38447-z. Nat Commun. 2023. PMID: 37179332 Free PMC article.
Regulation of chromatin accessibility by the histone chaperone CAF-1 sustains lineage fidelity.
Franklin R, Guo Y, He S, Chen M, Ji F, Zhou X, Frankhouser D, Do BT, Chiem C, Jang M, Blanco MA, Vander Heiden MG, Rockne RC, Ninova M, Sykes DB, Hochedlinger K, Lu R, Sadreyev RI, Murn J, Volk A, Cheloufi S. Franklin R, et al. Among authors: sykes db. Nat Commun. 2022 Apr 29;13(1):2350. doi: 10.1038/s41467-022-29730-6. Nat Commun. 2022. PMID: 35487911 Free PMC article.
The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of the transcription factor ERG.
Kugler E, Madiwale S, Yong D, Thoms JAI, Birger Y, Sykes DB, Schmoellerl J, Drakul A, Priebe V, Yassin M, Aqaqe N, Rein A, Fishman H, Geron I, Chen CW, Raught B, Liu Q, Ogana H, Liedke E, Bourquin JP, Zuber J, Milyavsky M, Pimanda J, Privé GG, Izraeli S. Kugler E, et al. Among authors: sykes db. Nat Commun. 2023 Sep 21;14(1):5871. doi: 10.1038/s41467-023-41067-2. Nat Commun. 2023. PMID: 37735473 Free PMC article.
Bone marrow-derived immature myeloid cells are a main source of circulating suPAR contributing to proteinuric kidney disease.
Hahm E, Wei C, Fernandez I, Li J, Tardi NJ, Tracy M, Wadhwani S, Cao Y, Peev V, Zloza A, Lusciks J, Hayek SS, O'Connor C, Bitzer M, Gupta V, Sever S, Sykes DB, Scadden DT, Reiser J. Hahm E, et al. Among authors: sykes db. Nat Med. 2017 Jan;23(1):100-106. doi: 10.1038/nm.4242. Epub 2016 Dec 12. Nat Med. 2017. PMID: 27941791 Free PMC article.
128 results