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S(+)-ketamine suppresses desensitization of γ-aminobutyric acid type B receptor-mediated signaling by inhibition of the interaction of γ-aminobutyric acid type B receptors with G protein-coupled receptor kinase 4 or 5.
Ando Y, Hojo M, Kanaide M, Takada M, Sudo Y, Shiraishi S, Sumikawa K, Uezono Y. Ando Y, et al. Among authors: uezono y. Anesthesiology. 2011 Feb;114(2):401-11. doi: 10.1097/ALN.0b013e318204e003. Anesthesiology. 2011. PMID: 21245733 Free article.
Possible involvement of prolonging spinal µ-opioid receptor desensitization in the development of antihyperalgesic tolerance to µ-opioids under a neuropathic pain-like state.
Narita M, Imai S, Nakamura A, Ozeki A, Asato M, Rahmadi M, Sudo Y, Hojo M, Uezono Y, Devi LA, Kuzumaki N, Suzuki T. Narita M, et al. Among authors: uezono y. Addict Biol. 2013 Jul;18(4):614-22. doi: 10.1111/j.1369-1600.2011.00354.x. Epub 2011 Aug 4. Addict Biol. 2013. PMID: 21812868 Free PMC article.
245 results