Toscano JP - Search Results

1

Hydropersulfides (RSSH) Outperform Post-Conditioning and Other Reactive Sulfur Species in Limiting Ischemia-Reperfusion Injury in the Isolated Mouse Heart.

Pharoah BM, Khodade VS, Eremiev A, Bao E, Liu T, O'Rourke B, Paolocci N, Toscano JP. Pharoah BM, et al. Among authors: toscano jp. Antioxidants (Basel). 2022 May 20;11(5):1010. doi: 10.3390/antiox11051010. Antioxidants (Basel). 2022. PMID: 35624878 Free PMC article.

2

Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.

Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, Kass DA, Paolocci N. Tocchetti CG, et al. Among authors: toscano jp. Circ Res. 2007 Jan 5;100(1):96-104. doi: 10.1161/01.RES.0000253904.53601.c9. Epub 2006 Nov 30. Circ Res. 2007. PMID: 17138943 Free PMC article.

3

Phospholamban thiols play a central role in activation of the cardiac muscle sarcoplasmic reticulum calcium pump by nitroxyl.

Froehlich JP, Mahaney JE, Keceli G, Pavlos CM, Goldstein R, Redwood AJ, Sumbilla C, Lee DI, Tocchetti CG, Kass DA, Paolocci N, Toscano JP. Froehlich JP, et al. Among authors: toscano jp. Biochemistry. 2008 Dec 16;47(50):13150-2. doi: 10.1021/bi801925p. Biochemistry. 2008. PMID: 19053265

4

HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.

Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N. Sivakumaran V, et al. Among authors: toscano jp. Antioxid Redox Signal. 2013 Oct 10;19(11):1185-97. doi: 10.1089/ars.2012.5057. Antioxid Redox Signal. 2013. PMID: 23919584 Free PMC article.

5

Chemical Biology of Hydropersulfides and Related Species: Possible Roles in Cellular Protection and Redox Signaling.

Álvarez L, Bianco CL, Toscano JP, Lin J, Akaike T, Fukuto JM. Álvarez L, et al. Among authors: toscano jp. Antioxid Redox Signal. 2017 Oct 1;27(10):622-633. doi: 10.1089/ars.2017.7081. Epub 2017 Jun 13. Antioxid Redox Signal. 2017. PMID: 28398141 Review.

6

Development of S-Substituted Thioisothioureas as Efficient Hydropersulfide Precursors.

Khodade VS, Toscano JP. Khodade VS, et al. Among authors: toscano jp. J Am Chem Soc. 2018 Dec 19;140(50):17333-17337. doi: 10.1021/jacs.8b08469. Epub 2018 Dec 6. J Am Chem Soc. 2018. PMID: 30507192

7

Nitroxyl (HNO) targets phospholamban cysteines 41 and 46 to enhance cardiac function.

Keceli G, Majumdar A, Thorpe CN, Jun S, Tocchetti CG, Lee DI, Mahaney JE, Paolocci N, Toscano JP. Keceli G, et al. Among authors: toscano jp. J Gen Physiol. 2019 Jun 3;151(6):758-770. doi: 10.1085/jgp.201812208. Epub 2019 Mar 6. J Gen Physiol. 2019. PMID: 30842219 Free PMC article.

8

Alkylamine-Substituted Perthiocarbamates: Dual Precursors to Hydropersulfide and Carbonyl Sulfide with Cardioprotective Actions.

Khodade VS, Pharoah BM, Paolocci N, Toscano JP. Khodade VS, et al. Among authors: toscano jp. J Am Chem Soc. 2020 Mar 4;142(9):4309-4316. doi: 10.1021/jacs.9b12180. Epub 2020 Feb 25. J Am Chem Soc. 2020. PMID: 32058717

9

Predicting the Possible Physiological/Biological Utility of the Hydropersulfide Functional Group Based on Its Chemistry: Similarities Between Hydropersulfides and Selenols.

Fukuto JM, Lin J, Khodade VS, Toscano JP. Fukuto JM, et al. Among authors: toscano jp. Antioxid Redox Signal. 2020 Dec 20;33(18):1295-1307. doi: 10.1089/ars.2020.8079. Epub 2020 Mar 31. Antioxid Redox Signal. 2020. PMID: 32103674

10

The reactions of hydropersulfides (RSSH) with myoglobin.

Álvarez L, Suarez Vega V, McGinity C, Khodade VS, Toscano JP, Nagy P, Lin J, Works C, Fukuto JM. Álvarez L, et al. Among authors: toscano jp. Arch Biochem Biophys. 2020 Jul 15;687:108391. doi: 10.1016/j.abb.2020.108391. Epub 2020 Apr 29. Arch Biochem Biophys. 2020. PMID: 32360749 Free article.

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