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Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling.
Tocchetti CG, Wang W, Froehlich JP, Huke S, Aon MA, Wilson GM, Di Benedetto G, O'Rourke B, Gao WD, Wink DA, Toscano JP, Zaccolo M, Bers DM, Valdivia HH, Cheng H, Kass DA, Paolocci N. Tocchetti CG, et al. Among authors: paolocci n. Circ Res. 2007 Jan 5;100(1):96-104. doi: 10.1161/01.RES.0000253904.53601.c9. Epub 2006 Nov 30. Circ Res. 2007. PMID: 17138943 Free PMC article.
GSH or palmitate preserves mitochondrial energetic/redox balance, preventing mechanical dysfunction in metabolically challenged myocytes/hearts from type 2 diabetic mice.
Tocchetti CG, Caceres V, Stanley BA, Xie C, Shi S, Watson WH, O'Rourke B, Spadari-Bratfisch RC, Cortassa S, Akar FG, Paolocci N, Aon MA. Tocchetti CG, et al. Among authors: paolocci n. Diabetes. 2012 Dec;61(12):3094-105. doi: 10.2337/db12-0072. Epub 2012 Jul 17. Diabetes. 2012. PMID: 22807033 Free PMC article.
HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
Sivakumaran V, Stanley BA, Tocchetti CG, Ballin JD, Caceres V, Zhou L, Keceli G, Rainer PP, Lee DI, Huke S, Ziolo MT, Kranias EG, Toscano JP, Wilson GM, O'Rourke B, Kass DA, Mahaney JE, Paolocci N. Sivakumaran V, et al. Among authors: paolocci n. Antioxid Redox Signal. 2013 Oct 10;19(11):1185-97. doi: 10.1089/ars.2012.5057. Antioxid Redox Signal. 2013. PMID: 23919584 Free PMC article.
Global knockout of ROMK potassium channel worsens cardiac ischemia-reperfusion injury but cardiomyocyte-specific knockout does not: Implications for the identity of mitoKATP.
Papanicolaou KN, Ashok D, Liu T, Bauer TM, Sun J, Li Z, da Costa E, D'Orleans CC, Nathan S, Lefer DJ, Murphy E, Paolocci N, Foster DB, O'Rourke B. Papanicolaou KN, et al. Among authors: paolocci n. J Mol Cell Cardiol. 2020 Feb;139:176-189. doi: 10.1016/j.yjmcc.2020.01.010. Epub 2020 Jan 29. J Mol Cell Cardiol. 2020. PMID: 32004507 Free PMC article.
159 results