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Conformational study into N-alkyl-N'-aryl ureas to inform drug discovery.
Stewart HL, Bon M, Wills C, Martin MP, Wang LZ, Mackenzie ES, Waddell PG, Waring MJ. Stewart HL, et al. Among authors: mackenzie es. Bioorg Med Chem. 2023 Aug 15;91:117387. doi: 10.1016/j.bmc.2023.117387. Epub 2023 Jun 20. Bioorg Med Chem. 2023. PMID: 37418825 Free article.
An ancient metalloenzyme evolves through metal preference modulation.
Sendra KM, Barwinska-Sendra A, Mackenzie ES, Baslé A, Kehl-Fie TE, Waldron KJ. Sendra KM, et al. Among authors: mackenzie es. Nat Ecol Evol. 2023 May;7(5):732-744. doi: 10.1038/s41559-023-02012-0. Epub 2023 Apr 10. Nat Ecol Evol. 2023. PMID: 37037909 Free PMC article.
Mirubactin C rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis.
Kepplinger B, Wen X, Tyler AR, Kim BY, Brown J, Banks P, Dashti Y, Mackenzie ES, Wills C, Kawai Y, Waldron KJ, Allenby NEE, Wu LJ, Hall MJ, Errington J. Kepplinger B, et al. Among authors: mackenzie es. Front Microbiol. 2022 Oct 13;13:1004737. doi: 10.3389/fmicb.2022.1004737. eCollection 2022. Front Microbiol. 2022. PMID: 36312962 Free PMC article.
Louise Eisenhardt (1891-1967): World Renowned Neuropathologist, Brain Tumor Registry Director, First Editor-In-Chief of Journal of Neurosurgery, and President of Harvey Cushing Society.
Ibrahim LI, Obetz K, Mackenzie ES, Jafar T, Kyoung I, Leininger K, Yudien MA, Shulkin JM, Sandoval A Jr, Uba A, Barrie U, Tissot MIJ, Detchou D, Howard SD. Ibrahim LI, et al. Among authors: mackenzie es. World Neurosurg. 2023 Feb;170:219-225. doi: 10.1016/j.wneu.2022.10.062. Epub 2022 Oct 21. World Neurosurg. 2023. PMID: 36280045
An evolutionary path to altered cofactor specificity in a metalloenzyme.
Barwinska-Sendra A, Garcia YM, Sendra KM, Baslé A, Mackenzie ES, Tarrant E, Card P, Tabares LC, Bicep C, Un S, Kehl-Fie TE, Waldron KJ. Barwinska-Sendra A, et al. Among authors: mackenzie es. Nat Commun. 2020 Jun 1;11(1):2738. doi: 10.1038/s41467-020-16478-0. Nat Commun. 2020. PMID: 32483131 Free PMC article.