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Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa.
Zhang L, Chen C, Fu J, Lilley B, Berlinicke C, Hansen B, Ding D, Wang G, Wang T, Shou D, Ye Y, Mulligan T, Emmerich K, Saxena MT, Hall KR, Sharrock AV, Brandon C, Park H, Kam TI, Dawson VL, Dawson TM, Shim JS, Hanes J, Ji H, Liu JO, Qian J, Ackerley DF, Rohrer B, Zack DJ, Mumm JS. Zhang L, et al. Among authors: ackerley df. Elife. 2021 Jun 29;10:e57245. doi: 10.7554/eLife.57245. Elife. 2021. PMID: 34184634 Free PMC article.
NTR 2.0: a rationally engineered prodrug-converting enzyme with substantially enhanced efficacy for targeted cell ablation.
Sharrock AV, Mulligan TS, Hall KR, Williams EM, White DT, Zhang L, Emmerich K, Matthews F, Nimmagadda S, Washington S, Le KD, Meir-Levi D, Cox OL, Saxena MT, Calof AL, Lopez-Burks ME, Lander AD, Ding D, Ji H, Ackerley DF, Mumm JS. Sharrock AV, et al. Among authors: ackerley df. Nat Methods. 2022 Feb;19(2):205-215. doi: 10.1038/s41592-021-01364-4. Epub 2022 Feb 7. Nat Methods. 2022. PMID: 35132245 Free PMC article.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Rich MH, Sharrock AV, Mulligan TS, Matthews F, Brown AS, Lee-Harwood HR, Williams EM, Copp JN, Little RF, Francis JJ, Horvat CN, Stevenson LJ, Owen JG, Saxena MT, Mumm JS, Ackerley DF. Rich MH, et al. Among authors: ackerley df. bioRxiv [Preprint]. 2023 Mar 25:2023.03.24.534183. doi: 10.1101/2023.03.24.534183. bioRxiv. 2023. PMID: 36993673 Free PMC article. Updated. Preprint.
An inducible model of chronic hyperglycemia.
Tucker TR, Knitter CA, Khoury DM, Eshghi S, Tran S, Sharrock AV, Wiles TJ, Ackerley DF, Mumm JS, Parsons MJ. Tucker TR, et al. Among authors: ackerley df. Dis Model Mech. 2023 Aug 1;16(8):dmm050215. doi: 10.1242/dmm.050215. Epub 2023 Aug 4. Dis Model Mech. 2023. PMID: 37401381 Free PMC article.
A metagenomic library cloning strategy that promotes high-level expression of captured genes to enable efficient functional screening.
Rich MH, Sharrock AV, Mulligan TS, Matthews F, Brown AS, Lee-Harwood HR, Williams EM, Copp JN, Little RF, Francis JJB, Horvat CN, Stevenson LJ, Owen JG, Saxena MT, Mumm JS, Ackerley DF. Rich MH, et al. Among authors: ackerley df. Cell Chem Biol. 2023 Dec 21;30(12):1680-1691.e6. doi: 10.1016/j.chembiol.2023.10.001. Epub 2023 Oct 27. Cell Chem Biol. 2023. PMID: 37898120
89 results