Xiang Y - Search Results

1

Activation of the membrane-bound Nrf1 transcription factor by USP19, a ubiquitin-specific protease C-terminally anchored in the endoplasmic reticulum.

Hu S, Xiang Y, Qiu L, Wang M, Zhang Y. Hu S, et al. Among authors: xiang y. Biochim Biophys Acta Mol Cell Res. 2022 Sep;1869(9):119299. doi: 10.1016/j.bbamcr.2022.119299. Epub 2022 May 22. Biochim Biophys Acta Mol Cell Res. 2022. PMID: 35613680 Free article.

2

The C-terminal domain of Nrf1 negatively regulates the full-length CNC-bZIP factor and its shorter isoform LCR-F1/Nrf1β; both are also inhibited by the small dominant-negative Nrf1γ/δ isoforms that down-regulate ARE-battery gene expression.

Zhang Y, Qiu L, Li S, Xiang Y, Chen J, Ren Y. Zhang Y, et al. Among authors: xiang y. PLoS One. 2014 Oct 7;9(10):e109159. doi: 10.1371/journal.pone.0109159. eCollection 2014. PLoS One. 2014. PMID: 25290918 Free PMC article.

3

The selective post-translational processing of transcription factor Nrf1 yields distinct isoforms that dictate its ability to differentially regulate gene expression.

Zhang Y, Li S, Xiang Y, Qiu L, Zhao H, Hayes JD. Zhang Y, et al. Among authors: xiang y. Sci Rep. 2015 Aug 13;5:12983. doi: 10.1038/srep12983. Sci Rep. 2015. PMID: 26268886 Free PMC article.

4

Molecular and cellular basis for the unique functioning of Nrf1, an indispensable transcription factor for maintaining cell homoeostasis and organ integrity.

Zhang Y, Xiang Y. Zhang Y, et al. Among authors: xiang y. Biochem J. 2016 Apr 15;473(8):961-1000. doi: 10.1042/BJ20151182. Biochem J. 2016. PMID: 27060105 Review.

5

TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells.

Ren Y, Qiu L, Lü F, Ru X, Li S, Xiang Y, Yu S, Zhang Y. Ren Y, et al. Among authors: xiang y. Sci Rep. 2016 Apr 11;6:23775. doi: 10.1038/srep23775. Sci Rep. 2016. PMID: 27065079 Free PMC article.

6

A Naturally-Occurring Dominant-Negative Inhibitor of Keap1 Competitively against Its Negative Regulation of Nrf2.

Qiu L, Wang M, Zhu Y, Xiang Y, Zhang Y. Qiu L, et al. Among authors: xiang y. Int J Mol Sci. 2018 Jul 24;19(8):2150. doi: 10.3390/ijms19082150. Int J Mol Sci. 2018. PMID: 30042301 Free PMC article.

7

Nach Is a Novel Subgroup at an Early Evolutionary Stage of the CNC-bZIP Subfamily Transcription Factors from the Marine Bacteria to Humans.

Zhu YP, Wang M, Xiang Y, Qiu L, Hu S, Zhang Z, Mattjus P, Zhu X, Zhang Y. Zhu YP, et al. Among authors: xiang y. Int J Mol Sci. 2018 Sep 26;19(10):2927. doi: 10.3390/ijms19102927. Int J Mol Sci. 2018. PMID: 30261635 Free PMC article.

8

Nrf1D Is the First Candidate Secretory Transcription Factor in the Blood Plasma, Its Precursor Existing as a Unique Redox-Sensitive Transmembrane CNC-bZIP Protein in Hemopoietic and Somatic Tissues.

Yuan J, Wang H, Xiang Y, Hu S, Li S, Wang M, Qiu L, Zhang Y. Yuan J, et al. Among authors: xiang y. Int J Mol Sci. 2018 Sep 27;19(10):2940. doi: 10.3390/ijms19102940. Int J Mol Sci. 2018. PMID: 30261697 Free PMC article.

9

Topovectorial mechanisms control the juxtamembrane proteolytic processing of Nrf1 to remove its N-terminal polypeptides during maturation of the CNC-bZIP factor.

Xiang Y, Halin J, Fan Z, Hu S, Wang M, Qiu L, Zhang Z, Mattjus P, Zhang Y. Xiang Y, et al. Toxicol Appl Pharmacol. 2018 Dec 1;360:160-184. doi: 10.1016/j.taap.2018.09.039. Epub 2018 Sep 28. Toxicol Appl Pharmacol. 2018. PMID: 30268580

10

Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits.

Xiang Y, Wang M, Hu S, Qiu L, Yang F, Zhang Z, Yu S, Pi J, Zhang Y. Xiang Y, et al. Toxicol Appl Pharmacol. 2018 Dec 1;360:212-235. doi: 10.1016/j.taap.2018.09.036. Epub 2018 Oct 1. Toxicol Appl Pharmacol. 2018. PMID: 30287392

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