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Response to supraphysiological testosterone is predicted by a distinct androgen receptor cistrome.
Qiu X, Brown LG, Conner JL, Nguyen HM, Boufaied N, Abou Alaiwi S, Seo JH, El Zarif T, Bell C, O'Connor E, Hanratty B, Pomerantz M, Freedman ML, Brown M, Haffner MC, Nelson PS, Feng FY, Labbé DP, Long HW, Corey E. Qiu X, et al. Among authors: labbe dp. JCI Insight. 2022 May 23;7(10):e157164. doi: 10.1172/jci.insight.157164. JCI Insight. 2022. PMID: 35603787 Free PMC article.
Role of diet in prostate cancer: the epigenetic link.
Labbé DP, Zadra G, Ebot EM, Mucci LA, Kantoff PW, Loda M, Brown M. Labbé DP, et al. Oncogene. 2015 Sep 3;34(36):4683-91. doi: 10.1038/onc.2014.422. Epub 2014 Dec 22. Oncogene. 2015. PMID: 25531313 Free PMC article. Review.
TOP2A and EZH2 Provide Early Detection of an Aggressive Prostate Cancer Subgroup.
Labbé DP, Sweeney CJ, Brown M, Galbo P, Rosario S, Wadosky KM, Ku SY, Sjöström M, Alshalalfa M, Erho N, Davicioni E, Karnes RJ, Schaeffer EM, Jenkins RB, Den RB, Ross AE, Bowden M, Huang Y, Gray KP, Feng FY, Spratt DE, Goodrich DW, Eng KH, Ellis L. Labbé DP, et al. Clin Cancer Res. 2017 Nov 15;23(22):7072-7083. doi: 10.1158/1078-0432.CCR-17-0413. Epub 2017 Sep 12. Clin Cancer Res. 2017. PMID: 28899973 Free PMC article.
Transcriptional Regulation in Prostate Cancer.
Labbé DP, Brown M. Labbé DP, et al. Cold Spring Harb Perspect Med. 2018 Nov 1;8(11):a030437. doi: 10.1101/cshperspect.a030437. Cold Spring Harb Perspect Med. 2018. PMID: 29530947 Free PMC article. Review.
EZH2 inhibition activates a dsRNA-STING-interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer.
Morel KL, Sheahan AV, Burkhart DL, Baca SC, Boufaied N, Liu Y, Qiu X, Cañadas I, Roehle K, Heckler M, Calagua C, Ye H, Pantelidou C, Galbo P, Panja S, Mitrofanova A, Wilkinson S, Whitlock NC, Trostel SY, Hamid AA, Kibel AS, Barbie DA, Choudhury AD, Pomerantz MM, Sweeney CJ, Long HW, Einstein DJ, Shapiro GI, Dougan SK, Sowalsky AG, He HH, Freedman ML, Balk SP, Loda M, Labbé DP, Olson BM, Ellis L. Morel KL, et al. Among authors: labbe dp. Nat Cancer. 2021 Apr;2(4):444-456. doi: 10.1038/s43018-021-00185-w. Epub 2021 Mar 22. Nat Cancer. 2021. PMID: 33899001 Free PMC article.
CdGAP promotes prostate cancer metastasis by regulating epithelial-to-mesenchymal transition, cell cycle progression, and apoptosis.
Mehra C, Chung JH, He Y, Lara-Márquez M, Goyette MA, Boufaied N, Barrès V, Ouellet V, Guérard KP, Delliaux C, Saad F, Lapointe J, Côté JF, Labbé DP, Lamarche-Vane N. Mehra C, et al. Among authors: labbe dp. Commun Biol. 2021 Sep 7;4(1):1042. doi: 10.1038/s42003-021-02520-4. Commun Biol. 2021. PMID: 34493786 Free PMC article.
MYC drives aggressive prostate cancer by disrupting transcriptional pause release at androgen receptor targets.
Qiu X, Boufaied N, Hallal T, Feit A, de Polo A, Luoma AM, Alahmadi W, Larocque J, Zadra G, Xie Y, Gu S, Tang Q, Zhang Y, Syamala S, Seo JH, Bell C, O'Connor E, Liu Y, Schaeffer EM, Jeffrey Karnes R, Weinmann S, Davicioni E, Morrissey C, Cejas P, Ellis L, Loda M, Wucherpfennig KW, Pomerantz MM, Spratt DE, Corey E, Freedman ML, Shirley Liu X, Brown M, Long HW, Labbé DP. Qiu X, et al. Among authors: labbe dp. Nat Commun. 2022 May 13;13(1):2559. doi: 10.1038/s41467-022-30257-z. Nat Commun. 2022. PMID: 35562350 Free PMC article.
28 results