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FK506 activates BMPR2, rescues endothelial dysfunction, and reverses pulmonary hypertension.
Spiekerkoetter E, Tian X, Cai J, Hopper RK, Sudheendra D, Li CG, El-Bizri N, Sawada H, Haghighat R, Chan R, Haghighat L, de Jesus Perez V, Wang L, Reddy S, Zhao M, Bernstein D, Solow-Cordero DE, Beachy PA, Wandless TJ, Ten Dijke P, Rabinovitch M. Spiekerkoetter E, et al. Among authors: reddy s. J Clin Invest. 2013 Aug;123(8):3600-13. doi: 10.1172/JCI65592. Epub 2013 Jul 15. J Clin Invest. 2013. PMID: 23867624 Free PMC article.
The vulnerable right ventricle.
Reddy S, Bernstein D. Reddy S, et al. Curr Opin Pediatr. 2015 Oct;27(5):563-8. doi: 10.1097/MOP.0000000000000268. Curr Opin Pediatr. 2015. PMID: 26262580 Free PMC article. Review.
De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects.
Priest JR, Osoegawa K, Mohammed N, Nanda V, Kundu R, Schultz K, Lammer EJ, Girirajan S, Scheetz T, Waggott D, Haddad F, Reddy S, Bernstein D, Burns T, Steimle JD, Yang XH, Moskowitz IP, Hurles M, Lifton RP, Nickerson D, Bamshad M, Eichler EE, Mital S, Sheffield V, Quertermous T, Gelb BD, Portman M, Ashley EA. Priest JR, et al. Among authors: reddy s. PLoS Genet. 2016 Apr 8;12(4):e1005963. doi: 10.1371/journal.pgen.1005963. eCollection 2016 Apr. PLoS Genet. 2016. PMID: 27058611 Free PMC article.
Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding.
Boehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter E. Boehm M, et al. Among authors: reddy s. Cardiovasc Res. 2020 Aug 1;116(10):1700-1709. doi: 10.1093/cvr/cvz310. Cardiovasc Res. 2020. PMID: 31738411 Free PMC article.
Noncanonical WNT Activation in Human Right Ventricular Heart Failure.
Edwards JJ, Brandimarto J, Hu DQ, Jeong S, Yucel N, Li L, Bedi KC Jr, Wada S, Murashige D, Hwang HTV, Zhao M, Margulies KB, Bernstein D, Reddy S, Arany Z. Edwards JJ, et al. Among authors: reddy s. Front Cardiovasc Med. 2020 Oct 7;7:582407. doi: 10.3389/fcvm.2020.582407. eCollection 2020. Front Cardiovasc Med. 2020. PMID: 33134326 Free PMC article.
Improving Right Ventricular Function by Increasing BMP Signaling with FK506.
Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Boehm M, et al. Among authors: reddy s. Am J Respir Cell Mol Biol. 2021 Sep;65(3):272-287. doi: 10.1165/rcmb.2020-0528OC. Am J Respir Cell Mol Biol. 2021. PMID: 33938785 Free PMC article.
MicroRNA-34a-Dependent Attenuation of Angiogenesis in Right Ventricular Failure.
Reddy S, Hu DQ, Zhao M, Ichimura S, Barnes EA, Cornfield DN, Alejandre Alcázar MA, Spiekerkoetter E, Fajardo G, Bernstein D. Reddy S, et al. J Am Heart Assoc. 2024 Feb 6;13(3):e029427. doi: 10.1161/JAHA.123.029427. Epub 2024 Jan 31. J Am Heart Assoc. 2024. PMID: 38293915 Free PMC article.
3D Imaging Reveals Complex Microvascular Remodeling in the Right Ventricle in Pulmonary Hypertension.
Ichimura K, Boehm M, Andruska AM, Zhang F, Schimmel K, Bonham S, Kabiri A, Kheyfets VO, Ichimura S, Reddy S, Mao Y, Zhang T, Wang G, Santana EJ, Tian X, Essafri I, Vinh R, Tian W, Nicolls MR, Yajima S, Shudo Y, MacArthur JW, Woo YJ, Metzger RJ, Spiekerkoetter E. Ichimura K, et al. Among authors: reddy s. Circ Res. 2024 May 21. doi: 10.1161/CIRCRESAHA.123.323546. Online ahead of print. Circ Res. 2024. PMID: 38770652
Molecular Mechanisms of Right Ventricular Failure.
Reddy S, Bernstein D. Reddy S, et al. Circulation. 2015 Nov 3;132(18):1734-42. doi: 10.1161/CIRCULATIONAHA.114.012975. Circulation. 2015. PMID: 26527692 Free PMC article. Review.
5,157 results