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Aspartate metabolism in endothelial cells activates the mTORC1 pathway to initiate translation during angiogenesis.
Oberkersch RE, Pontarin G, Astone M, Spizzotin M, Arslanbaeva L, Tosi G, Panieri E, Ricciardi S, Allega MF, Brossa A, Grumati P, Bussolati B, Biffo S, Tardito S, Santoro MM. Oberkersch RE, et al. Among authors: biffo s. Dev Cell. 2022 May 23;57(10):1241-1256.e8. doi: 10.1016/j.devcel.2022.04.018. Epub 2022 May 16. Dev Cell. 2022. PMID: 35580611 Free article.
eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription.
Brina D, Miluzio A, Ricciardi S, Clarke K, Davidsen PK, Viero G, Tebaldi T, Offenhäuser N, Rozman J, Rathkolb B, Neschen S, Klingenspor M, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Quattrone A, Falciani F, Biffo S. Brina D, et al. Among authors: biffo s. Nat Commun. 2015 Sep 18;6:8261. doi: 10.1038/ncomms9261. Nat Commun. 2015. PMID: 26383020 Free PMC article.
SBDS-Deficient Cells Have an Altered Homeostatic Equilibrium due to Translational Inefficiency Which Explains their Reduced Fitness and Provides a Logical Framework for Intervention.
Calamita P, Miluzio A, Russo A, Pesce E, Ricciardi S, Khanim F, Cheroni C, Alfieri R, Mancino M, Gorrini C, Rossetti G, Peluso I, Pagani M, Medina DL, Rommens J, Biffo S. Calamita P, et al. Among authors: biffo s. PLoS Genet. 2017 Jan 5;13(1):e1006552. doi: 10.1371/journal.pgen.1006552. eCollection 2017 Jan. PLoS Genet. 2017. PMID: 28056084 Free PMC article.
High levels of eukaryotic Initiation Factor 6 (eIF6) are required for immune system homeostasis and for steering the glycolytic flux of TCR-stimulated CD4+ T cells in both mice and humans.
Manfrini N, Ricciardi S, Miluzio A, Fedeli M, Scagliola A, Gallo S, Brina D, Adler T, Busch DH, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Biffo S. Manfrini N, et al. Among authors: biffo s. Dev Comp Immunol. 2017 Dec;77:69-76. doi: 10.1016/j.dci.2017.07.022. Epub 2017 Jul 22. Dev Comp Immunol. 2017. PMID: 28743432
Crosstalks between translation and metabolism in cancer.
Biffo S, Manfrini N, Ricciardi S. Biffo S, et al. Curr Opin Genet Dev. 2018 Feb;48:75-81. doi: 10.1016/j.gde.2017.10.011. Epub 2017 Nov 15. Curr Opin Genet Dev. 2018. PMID: 29153483 Review.
106 results