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Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure.
Luraghi A, Ferrandi M, Barassi P, Arici M, Hsu SC, Torre E, Ronchi C, Romerio A, Chang GJ, Ferrari P, Bianchi G, Zaza A, Rocchetti M, Peri F. Luraghi A, et al. Among authors: barassi p. J Med Chem. 2022 May 26;65(10):7324-7333. doi: 10.1021/acs.jmedchem.2c00347. Epub 2022 May 17. J Med Chem. 2022. PMID: 35580334 Free PMC article.
17beta-O-Aminoalkyloximes of 5beta-androstane-3beta,14beta-diol with digitalis-like activity: synthesis, cardiotonic activity, structure-activity relationships, and molecular modeling of the Na(+),K(+)-ATPase receptor.
Cerri A, Almirante N, Barassi P, Benicchio A, Fedrizzi G, Ferrari P, Micheletti R, Quadri L, Ragg E, Rossi R, Santagostino M, Schiavone A, Serra F, Zappavigna MP, Melloni P. Cerri A, et al. Among authors: barassi p. J Med Chem. 2000 Jun 15;43(12):2332-49. doi: 10.1021/jm990627w. J Med Chem. 2000. PMID: 10882359
Antihypertensive compounds that modulate the Na-K pump.
Ferrari P, Ferrandi M, Torielli L, Barassi P, Tripodi G, Minotti E, Molinari I, Melloni P, Bianchi G. Ferrari P, et al. Among authors: barassi p. Ann N Y Acad Sci. 2003 Apr;986:694-701. doi: 10.1111/j.1749-6632.2003.tb07284.x. Ann N Y Acad Sci. 2003. PMID: 12763920 Review.
Ouabain antagonists as antihypertensive agents.
Ferrandi M, Barassi P, Molinari I, Torielli L, Tripodi G, Minotti E, Bianchi G, Ferrari P. Ferrandi M, et al. Among authors: barassi p. Curr Pharm Des. 2005;11(25):3301-5. doi: 10.2174/138161205774424735. Curr Pharm Des. 2005. PMID: 16250857 Review.
Modulation of sarcoplasmic reticulum function by PST2744 [istaroxime; (E,Z)-3-((2-aminoethoxy)imino) androstane-6,17-dione hydrochloride)] in a pressure-overload heart failure model.
Rocchetti M, Alemanni M, Mostacciuolo G, Barassi P, Altomare C, Chisci R, Micheletti R, Ferrari P, Zaza A. Rocchetti M, et al. Among authors: barassi p. J Pharmacol Exp Ther. 2008 Sep;326(3):957-65. doi: 10.1124/jpet.108.138701. Epub 2008 Jun 6. J Pharmacol Exp Ther. 2008. PMID: 18539651
18 results