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Inflammation-Independent Antinociceptive Effects of DF2755A, a CXCR1/2 Selective Inhibitor: A New Potential Therapeutic Treatment for Peripheral Neuropathy Associated to Non-Ulcerative Interstitial Cystitis/Bladder Pain Syndrome.
Brandolini L, Aramini A, Bianchini G, Ruocco A, Bertini R, Novelli R, Angelico P, Valsecchi AE, Russo R, Castelli V, Cimini A, Allegretti M. Brandolini L, et al. Among authors: valsecchi ae. Front Pharmacol. 2022 Apr 28;13:854238. doi: 10.3389/fphar.2022.854238. eCollection 2022. Front Pharmacol. 2022. PMID: 35571079 Free PMC article.
Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.
Graziani D, Caligari S, Callegari E, De Toma C, Longhi M, Frigerio F, Dilernia R, Menegon S, Pinzi L, Pirona L, Tazzari V, Valsecchi AE, Vistoli G, Rastelli G, Riva C. Graziani D, et al. Among authors: valsecchi ae. J Med Chem. 2019 Feb 14;62(3):1246-1273. doi: 10.1021/acs.jmedchem.8b01226. Epub 2019 Jan 28. J Med Chem. 2019. PMID: 30624919
JNK signaling provides a novel therapeutic target for Rett syndrome.
Musi CA, Castaldo AM, Valsecchi AE, Cimini S, Morello N, Pizzo R, Renieri A, Meloni I, Bonati M, Giustetto M, Borsello T. Musi CA, et al. Among authors: valsecchi ae. BMC Biol. 2021 Dec 16;19(1):256. doi: 10.1186/s12915-021-01190-2. BMC Biol. 2021. PMID: 34911542 Free PMC article.
The purinergic antagonist PPADS reduces pain related behaviours and interleukin-1 beta, interleukin-6, iNOS and nNOS overproduction in central and peripheral nervous system after peripheral neuropathy in mice.
Martucci C, Trovato AE, Costa B, Borsani E, Franchi S, Magnaghi V, Panerai AE, Rodella LF, Valsecchi AE, Sacerdote P, Colleoni M. Martucci C, et al. Among authors: valsecchi ae. Pain. 2008 Jul;137(1):81-95. doi: 10.1016/j.pain.2007.08.017. Epub 2007 Sep 27. Pain. 2008. PMID: 17900807