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Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism.
Hoffman NJ, Whitfield J, Janzen NR, Belhaj MR, Galic S, Murray-Segal L, Smiles WJ, Ling NXY, Dite TA, Scott JW, Oakhill JS, Brink R, Kemp BE, Hawley JA. Hoffman NJ, et al. Among authors: kemp be. Mol Metab. 2020 Nov;41:101048. doi: 10.1016/j.molmet.2020.101048. Epub 2020 Jun 29. Mol Metab. 2020. PMID: 32610071 Free PMC article.
Salsalate reduces atherosclerosis through AMPKβ1 in mice.
Day EA, Ford RJ, Smith BK, Houde VP, Stypa S, Rehal S, Lhotak S, Kemp BE, Trigatti BL, Werstuck GH, Austin RC, Fullerton MD, Steinberg GR. Day EA, et al. Among authors: kemp be. Mol Metab. 2021 Nov;53:101321. doi: 10.1016/j.molmet.2021.101321. Epub 2021 Aug 21. Mol Metab. 2021. PMID: 34425254 Free PMC article.
Salicylate improves macrophage cholesterol homeostasis via activation of Ampk.
Fullerton MD, Ford RJ, McGregor CP, LeBlond ND, Snider SA, Stypa SA, Day EA, Lhoták Š, Schertzer JD, Austin RC, Kemp BE, Steinberg GR. Fullerton MD, et al. Among authors: kemp be. J Lipid Res. 2015 May;56(5):1025-33. doi: 10.1194/jlr.M058875. Epub 2015 Mar 15. J Lipid Res. 2015. PMID: 25773887 Free PMC article.
AMPK β1 reduces tumor progression and improves survival in p53 null mice.
Houde VP, Donzelli S, Sacconi A, Galic S, Hammill JA, Bramson JL, Foster RA, Tsakiridis T, Kemp BE, Grasso G, Blandino G, Muti P, Steinberg GR. Houde VP, et al. Among authors: kemp be. Mol Oncol. 2017 Sep;11(9):1143-1155. doi: 10.1002/1878-0261.12079. Epub 2017 Jun 28. Mol Oncol. 2017. PMID: 28544264 Free PMC article.
Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1 isoforms.
Pinkosky SL, Scott JW, Desjardins EM, Smith BK, Day EA, Ford RJ, Langendorf CG, Ling NXY, Nero TL, Loh K, Galic S, Hoque A, Smiles WJ, Ngoei KRW, Parker MW, Yan Y, Melcher K, Kemp BE, Oakhill JS, Steinberg GR. Pinkosky SL, et al. Among authors: kemp be. Nat Metab. 2020 Sep;2(9):873-881. doi: 10.1038/s42255-020-0245-2. Epub 2020 Jul 27. Nat Metab. 2020. PMID: 32719536 Free PMC article.
420 results