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Elevation of fatty acid desaturase 2 in esophageal adenocarcinoma increases polyunsaturated lipids and may exacerbate bile acid-induced DNA damage.
Molendijk J, Kolka CM, Cairns H, Brosda S, Mohamed A, Shah AK, Brown I, Hodson MP, Hennessy T, Liu G, Stoll T, Richards RS, Gartside M, Patel K, Clemons NJ, Phillips WA, Barbour A, Westerhuis JA, Hill MM. Molendijk J, et al. Among authors: phillips wa. Clin Transl Med. 2022 May;12(5):e810. doi: 10.1002/ctm2.810. Clin Transl Med. 2022. PMID: 35560527 Free PMC article.
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.
Wang DH, Clemons NJ, Miyashita T, Dupuy AJ, Zhang W, Szczepny A, Corcoran-Schwartz IM, Wilburn DL, Montgomery EA, Wang JS, Jenkins NA, Copeland NA, Harmon JW, Phillips WA, Watkins DN. Wang DH, et al. Among authors: phillips wa. Gastroenterology. 2010 May;138(5):1810-22. doi: 10.1053/j.gastro.2010.01.048. Epub 2010 Feb 4. Gastroenterology. 2010. PMID: 20138038 Free PMC article.
Sox9 drives columnar differentiation of esophageal squamous epithelium: a possible role in the pathogenesis of Barrett's esophagus.
Clemons NJ, Wang DH, Croagh D, Tikoo A, Fennell CM, Murone C, Scott AM, Watkins DN, Phillips WA. Clemons NJ, et al. Among authors: phillips wa. Am J Physiol Gastrointest Liver Physiol. 2012 Dec 15;303(12):G1335-46. doi: 10.1152/ajpgi.00291.2012. Epub 2012 Oct 11. Am J Physiol Gastrointest Liver Physiol. 2012. PMID: 23064761 Free article.
Barrett's esophagus: cancer and molecular biology.
Gibson MK, Dhaliwal AS, Clemons NJ, Phillips WA, Dvorak K, Tong D, Law S, Pirchi ED, Räsänen J, Krasna MJ, Parikh K, Krishnadath KK, Chen Y, Griffiths L, Colleypriest BJ, Farrant JM, Tosh D, Das KM, Bajpai M. Gibson MK, et al. Among authors: phillips wa. Ann N Y Acad Sci. 2013 Oct;1300:296-314. doi: 10.1111/nyas.12252. Ann N Y Acad Sci. 2013. PMID: 24117650 Review.
Translational research on Barrett's esophagus.
Baruah A, Buttar N, Chandra R, Chen X, Clemons NJ, Compare D, El-Rifai W, Gu J, Houchen CW, Koh SY, Li W, Nardone G, Phillips WA, Sharma A, Singh I, Upton MP, Vega KJ, Wu X. Baruah A, et al. Among authors: phillips wa. Ann N Y Acad Sci. 2014 Sep;1325:170-86. doi: 10.1111/nyas.12531. Ann N Y Acad Sci. 2014. PMID: 25266024
Genomic catastrophes frequently arise in esophageal adenocarcinoma and drive tumorigenesis.
Nones K, Waddell N, Wayte N, Patch AM, Bailey P, Newell F, Holmes O, Fink JL, Quinn MCJ, Tang YH, Lampe G, Quek K, Loffler KA, Manning S, Idrisoglu S, Miller D, Xu Q, Waddell N, Wilson PJ, Bruxner TJC, Christ AN, Harliwong I, Nourse C, Nourbakhsh E, Anderson M, Kazakoff S, Leonard C, Wood S, Simpson PT, Reid LE, Krause L, Hussey DJ, Watson DI, Lord RV, Nancarrow D, Phillips WA, Gotley D, Smithers BM, Whiteman DC, Hayward NK, Campbell PJ, Pearson JV, Grimmond SM, Barbour AP. Nones K, et al. Among authors: phillips wa. Nat Commun. 2014 Oct 29;5:5224. doi: 10.1038/ncomms6224. Nat Commun. 2014. PMID: 25351503 Free PMC article.
304 results