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Potent neutralization by monoclonal human IgM against SARS-CoV-2 is impaired by class switch.
Callegari I, Schneider M, Berloffa G, Mühlethaler T, Holdermann S, Galli E, Roloff T, Boss R, Infanti L, Khanna N, Egli A, Buser A, Zimmer G, Derfuss T, Sanderson NSR. Callegari I, et al. Among authors: muhlethaler t. EMBO Rep. 2022 Jul 5;23(7):e53956. doi: 10.15252/embr.202153956. Epub 2022 May 12. EMBO Rep. 2022. PMID: 35548920 Free PMC article.
Improvement of Aglycone π-Stacking Yields Nanomolar to Sub-nanomolar FimH Antagonists.
Schönemann W, Cramer J, Mühlethaler T, Fiege B, Silbermann M, Rabbani S, Dätwyler P, Zihlmann P, Jakob RP, Sager CP, Smieško M, Schwardt O, Maier T, Ernst B. Schönemann W, et al. Among authors: muhlethaler t. ChemMedChem. 2019 Apr 3;14(7):749-757. doi: 10.1002/cmdc.201900051. Epub 2019 Feb 22. ChemMedChem. 2019. PMID: 30710416
Prodrugs of E-selectin Antagonists with Enhanced Pharmacokinetic Properties.
Dätwyler P, Jiang X, Wagner B, Varga N, Mühlethaler T, Hostettler K, Rabbani S, Schwardt O, Ernst B. Dätwyler P, et al. Among authors: muhlethaler t. ChemMedChem. 2022 Jan 5;17(1):e202100634. doi: 10.1002/cmdc.202100634. Epub 2021 Dec 6. ChemMedChem. 2022. PMID: 34870892
Comprehensive Analysis of Binding Sites in Tubulin.
Mühlethaler T, Gioia D, Prota AE, Sharpe ME, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Angew Chem Int Ed Engl. 2021 Jun 7;60(24):13331-13342. doi: 10.1002/anie.202100273. Epub 2021 May 5. Angew Chem Int Ed Engl. 2021. PMID: 33951246 Free PMC article.
Rational Design of a Novel Tubulin Inhibitor with a Unique Mechanism of Action.
Mühlethaler T, Milanos L, Ortega JA, Blum TB, Gioia D, Roy B, Prota AE, Cavalli A, Steinmetz MO. Mühlethaler T, et al. Angew Chem Int Ed Engl. 2022 Jun 20;61(25):e202204052. doi: 10.1002/anie.202204052. Epub 2022 Apr 25. Angew Chem Int Ed Engl. 2022. PMID: 35404502 Free PMC article.
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