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MEF2C opposes Notch in lymphoid lineage decision and drives leukemia in the thymus.
Canté-Barrett K, Meijer MT, Cordo' V, Hagelaar R, Yang W, Yu J, Smits WK, Nulle ME, Jansen JP, Pieters R, Yang JJ, Haigh JJ, Goossens S, Meijerink JP. Canté-Barrett K, et al. Among authors: haigh jj. JCI Insight. 2022 Jul 8;7(13):e150363. doi: 10.1172/jci.insight.150363. JCI Insight. 2022. PMID: 35536646 Free PMC article.
Vegf regulates embryonic erythroid development through Gata1 modulation.
Drogat B, Kalucka J, Gutiérrez L, Hammad H, Goossens S, Farhang Ghahremani M, Bartunkova S, Haigh K, Deswarte K, Nyabi O, Naessens M, Ferrara N, Klingmüller U, Lambrecht BN, Nagy A, Philipsen S, Haigh JJ. Drogat B, et al. Among authors: haigh jj, haigh k. Blood. 2010 Sep 23;116(12):2141-51. doi: 10.1182/blood-2010-01-264143. Epub 2010 Jun 16. Blood. 2010. PMID: 20554972 Free article.
The EMT regulator Zeb2/Sip1 is essential for murine embryonic hematopoietic stem/progenitor cell differentiation and mobilization.
Goossens S, Janzen V, Bartunkova S, Yokomizo T, Drogat B, Crisan M, Haigh K, Seuntjens E, Umans L, Riedt T, Bogaert P, Haenebalcke L, Berx G, Dzierzak E, Huylebroeck D, Haigh JJ. Goossens S, et al. Among authors: haigh jj, haigh k. Blood. 2011 May 26;117(21):5620-30. doi: 10.1182/blood-2010-08-300236. Epub 2011 Feb 25. Blood. 2011. PMID: 21355089 Free article.
ZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.
Goossens S, Radaelli E, Blanchet O, Durinck K, Van der Meulen J, Peirs S, Taghon T, Tremblay CS, Costa M, Farhang Ghahremani M, De Medts J, Bartunkova S, Haigh K, Schwab C, Farla N, Pieters T, Matthijssens F, Van Roy N, Best JA, Deswarte K, Bogaert P, Carmichael C, Rickard A, Suryani S, Bracken LS, Alserihi R, Canté-Barrett K, Haenebalcke L, Clappier E, Rondou P, Slowicka K, Huylebroeck D, Goldrath AW, Janzen V, McCormack MP, Lock RB, Curtis DJ, Harrison C, Berx G, Speleman F, Meijerink JP, Soulier J, Van Vlierberghe P, Haigh JJ. Goossens S, et al. Among authors: haigh jj, haigh k. Nat Commun. 2015 Jan 7;6:5794. doi: 10.1038/ncomms6794. Nat Commun. 2015. PMID: 25565005 Free PMC article.
Novel biological insights in T-cell acute lymphoblastic leukemia.
Durinck K, Goossens S, Peirs S, Wallaert A, Van Loocke W, Matthijssens F, Pieters T, Milani G, Lammens T, Rondou P, Van Roy N, De Moerloose B, Benoit Y, Haigh J, Speleman F, Poppe B, Van Vlierberghe P. Durinck K, et al. Exp Hematol. 2015 Aug;43(8):625-39. doi: 10.1016/j.exphem.2015.05.017. Epub 2015 Jun 26. Exp Hematol. 2015. PMID: 26123366 Free article. Review.
The EMT transcription factor Zeb2 controls adult murine hematopoietic differentiation by regulating cytokine signaling.
Li J, Riedt T, Goossens S, Carrillo García C, Szczepanski S, Brandes M, Pieters T, Dobrosch L, Gütgemann I, Farla N, Radaelli E, Hulpiau P, Mallela N, Fröhlich H, La Starza R, Matteucci C, Chen T, Brossart P, Mecucci C, Huylebroeck D, Haigh JJ, Janzen V. Li J, et al. Among authors: haigh jj. Blood. 2017 Jan 26;129(4):460-472. doi: 10.1182/blood-2016-05-714659. Epub 2016 Sep 28. Blood. 2017. PMID: 27683414 Free article.
Oncogenic ZEB2 activation drives sensitivity toward KDM1A inhibition in T-cell acute lymphoblastic leukemia.
Goossens S, Peirs S, Van Loocke W, Wang J, Takawy M, Matthijssens F, Sonderegger SE, Haigh K, Nguyen T, Vandamme N, Costa M, Carmichael C, Van Nieuwerburgh F, Deforce D, Kleifeld O, Curtis DJ, Berx G, Van Vlierberghe P, Haigh JJ. Goossens S, et al. Among authors: haigh jj, haigh k. Blood. 2017 Feb 23;129(8):981-990. doi: 10.1182/blood-2016-06-721191. Epub 2017 Jan 9. Blood. 2017. PMID: 28069602 Free PMC article.
107 results