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Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker.
Mansurov A, Hosseinchi P, Chang K, Lauterbach AL, Gray LT, Alpar AT, Budina E, Slezak AJ, Kang S, Cao S, Solanki A, Gomes S, Williford JM, Swartz MA, Mendoza JL, Ishihara J, Hubbell JA. Mansurov A, et al. Among authors: williford jm. Nat Biomed Eng. 2022 Jul;6(7):819-829. doi: 10.1038/s41551-022-00888-0. Epub 2022 May 9. Nat Biomed Eng. 2022. PMID: 35534574
Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours.
Mansurov A, Ishihara J, Hosseinchi P, Potin L, Marchell TM, Ishihara A, Williford JM, Alpar AT, Raczy MM, Gray LT, Swartz MA, Hubbell JA. Mansurov A, et al. Among authors: williford jm. Nat Biomed Eng. 2020 May;4(5):531-543. doi: 10.1038/s41551-020-0549-2. Epub 2020 Apr 13. Nat Biomed Eng. 2020. PMID: 32284554 Free PMC article.
Targeted antibody and cytokine cancer immunotherapies through collagen affinity.
Ishihara J, Ishihara A, Sasaki K, Lee SS, Williford JM, Yasui M, Abe H, Potin L, Hosseinchi P, Fukunaga K, Raczy MM, Gray LT, Mansurov A, Katsumata K, Fukayama M, Kron SJ, Swartz MA, Hubbell JA. Ishihara J, et al. Among authors: williford jm. Sci Transl Med. 2019 Apr 10;11(487):eaau3259. doi: 10.1126/scitranslmed.aau3259. Sci Transl Med. 2019. PMID: 30971453 Free PMC article.
Recent advances in nanoparticle-mediated siRNA delivery.
Williford JM, Wu J, Ren Y, Archang MM, Leong KW, Mao HQ. Williford JM, et al. Annu Rev Biomed Eng. 2014 Jul 11;16:347-70. doi: 10.1146/annurev-bioeng-071813-105119. Epub 2014 Jun 2. Annu Rev Biomed Eng. 2014. PMID: 24905873 Review.
Control of polymeric nanoparticle size to improve therapeutic delivery.
Hickey JW, Santos JL, Williford JM, Mao HQ. Hickey JW, et al. Among authors: williford jm. J Control Release. 2015 Dec 10;219:536-547. doi: 10.1016/j.jconrel.2015.10.006. Epub 2015 Oct 9. J Control Release. 2015. PMID: 26450667 Free PMC article. Review.
16 results