Gohlke H - Search Results

1

Co-culture of the fungus Fusarium tricinctum with Streptomyces lividans induces production of cryptic naphthoquinone dimers.

Moussa M, Ebrahim W, Bonus M, Gohlke H, Mándi A, Kurtán T, Hartmann R, Kalscheuer R, Lin W, Liu Z, Proksch P. Moussa M, et al. Among authors: gohlke h. RSC Adv. 2019 Jan 11;9(3):1491-1500. doi: 10.1039/c8ra09067j. eCollection 2019 Jan 9. RSC Adv. 2019. PMID: 35518011 Free PMC article.

2

EDTA aggregates induce SYPRO orange-based fluorescence in thermal shift assay.

Kroeger T, Frieg B, Zhang T, Hansen FK, Marmann A, Proksch P, Nagel-Steger L, Groth G, Smits SHJ, Gohlke H. Kroeger T, et al. Among authors: gohlke h. PLoS One. 2017 May 4;12(5):e0177024. doi: 10.1371/journal.pone.0177024. eCollection 2017. PLoS One. 2017. PMID: 28472107 Free PMC article.

3

Sequencing of FIC1, BSEP and MDR3 in a large cohort of patients with cholestasis revealed a high number of different genetic variants.

Dröge C, Bonus M, Baumann U, Klindt C, Lainka E, Kathemann S, Brinkert F, Grabhorn E, Pfister ED, Wenning D, Fichtner A, Gotthardt DN, Weiss KH, McKiernan P, Puri RD, Verma IC, Kluge S, Gohlke H, Schmitt L, Kubitz R, Häussinger D, Keitel V. Dröge C, et al. Among authors: gohlke h. J Hepatol. 2017 Dec;67(6):1253-1264. doi: 10.1016/j.jhep.2017.07.004. Epub 2017 Jul 19. J Hepatol. 2017. PMID: 28733223

4

Chlorflavonin Targets Acetohydroxyacid Synthase Catalytic Subunit IlvB1 for Synergistic Killing of Mycobacterium tuberculosis.

Rehberg N, Akone HS, Ioerger TR, Erlenkamp G, Daletos G, Gohlke H, Proksch P, Kalscheuer R. Rehberg N, et al. Among authors: gohlke h. ACS Infect Dis. 2018 Feb 9;4(2):123-134. doi: 10.1021/acsinfecdis.7b00055. Epub 2017 Nov 16. ACS Infect Dis. 2018. PMID: 29108416

5

Hydrophobic alkyl chains substituted to the 8-position of cyclic nucleotides enhance activation of CNG and HCN channels by an intricate enthalpy - entropy compensation.

Otte M, Schweinitz A, Bonus M, Enke U, Schumann C, Gohlke H, Benndorf K. Otte M, et al. Among authors: gohlke h. Sci Rep. 2018 Oct 8;8(1):14960. doi: 10.1038/s41598-018-33050-5. Sci Rep. 2018. PMID: 30297855 Free PMC article.

6

FK506 Resistance of Saccharomyces cerevisiae Pdr5 and Candida albicans Cdr1 Involves Mutations in the Transmembrane Domains and Extracellular Loops.

Tanabe K, Bonus M, Tomiyama S, Miyoshi K, Nagi M, Niimi K, Chindamporn A, Gohlke H, Schmitt L, Cannon RD, Niimi M, Lamping E. Tanabe K, et al. Among authors: gohlke h. Antimicrob Agents Chemother. 2018 Dec 21;63(1):e01146-18. doi: 10.1128/AAC.01146-18. Print 2019 Jan. Antimicrob Agents Chemother. 2018. PMID: 30348662 Free PMC article.

7

Novel 3,4-Dihydroisocoumarins Inhibit Human P-gp and BCRP in Multidrug Resistant Tumors and Demonstrate Substrate Inhibition of Yeast Pdr5.

Sachs J, Döhl K, Weber A, Bonus M, Ehlers F, Fleischer E, Klinger A, Gohlke H, Pietruszka J, Schmitt L, Teusch N. Sachs J, et al. Among authors: gohlke h. Front Pharmacol. 2019 Apr 16;10:400. doi: 10.3389/fphar.2019.00400. eCollection 2019. Front Pharmacol. 2019. PMID: 31040786 Free PMC article.

8

Novel Fluorescent Cyclic Nucleotide Derivatives to Study CNG and HCN Channel Function.

Otte M, Schweinitz A, Lelle M, Thon S, Enke U, Yüksel S, Schmauder R, Bonus M, Gohlke H, Benndorf K. Otte M, et al. Among authors: gohlke h. Biophys J. 2019 Jun 18;116(12):2411-2422. doi: 10.1016/j.bpj.2019.05.006. Epub 2019 May 10. Biophys J. 2019. PMID: 31130235 Free PMC article.

9

Isoform-specific Inhibition of N-methyl-D-aspartate Receptors by Bile Salts.

Koch A, Bonus M, Gohlke H, Klöcker N. Koch A, et al. Among authors: gohlke h. Sci Rep. 2019 Jul 11;9(1):10068. doi: 10.1038/s41598-019-46496-y. Sci Rep. 2019. PMID: 31296930 Free PMC article.

10

Biallelic mutation of human SLC6A6 encoding the taurine transporter TAUT is linked to early retinal degeneration.

Preising MN, Görg B, Friedburg C, Qvartskhava N, Budde BS, Bonus M, Toliat MR, Pfleger C, Altmüller J, Herebian D, Beyer M, Zöllner HJ, Wittsack HJ, Schaper J, Klee D, Zechner U, Nürnberg P, Schipper J, Schnitzler A, Gohlke H, Lorenz B, Häussinger D, Bolz HJ. Preising MN, et al. Among authors: gohlke h. FASEB J. 2019 Oct;33(10):11507-11527. doi: 10.1096/fj.201900914RR. Epub 2019 Jul 25. FASEB J. 2019. PMID: 31345061

TAUT(p.A78E) still localized in the plasma membrane but is predicted to impact structural stabilization. (3)H-taurine uptake by peripheral blood mononuclear cells was reduced by 95%, and taurine levels were severely reduced in plasma, skeletal muscle, and brain. ...R., Pfl …

TAUT(p.A78E) still localized in the plasma membrane but is predicted to impact structural stabilization. (3)H-taurine uptake by perip …

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