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Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1.
Aykul S, Huang L, Wang L, Das NM, Reisman S, Ray Y, Zhang Q, Rothman N, Nannuru KC, Kamat V, Brydges S, Troncone L, Johnsen L, Yu PB, Fazio S, Lees-Shepard J, Schutz K, Murphy AJ, Economides AN, Idone V, Hatsell SJ. Aykul S, et al. Among authors: yu pb. J Clin Invest. 2022 Jun 15;132(12):e153792. doi: 10.1172/JCI153792. J Clin Invest. 2022. PMID: 35511419 Free PMC article.
Constitutively active ALK2 receptor mutants require type II receptor cooperation.
Bagarova J, Vonner AJ, Armstrong KA, Börgermann J, Lai CS, Deng DY, Beppu H, Alfano I, Filippakopoulos P, Morrell NW, Bullock AN, Knaus P, Mishina Y, Yu PB. Bagarova J, et al. Among authors: yu pb. Mol Cell Biol. 2013 Jun;33(12):2413-24. doi: 10.1128/MCB.01595-12. Epub 2013 Apr 9. Mol Cell Biol. 2013. PMID: 23572558 Free PMC article.
ACVR1R206H receptor mutation causes fibrodysplasia ossificans progressiva by imparting responsiveness to activin A.
Hatsell SJ, Idone V, Wolken DM, Huang L, Kim HJ, Wang L, Wen X, Nannuru KC, Jimenez J, Xie L, Das N, Makhoul G, Chernomorsky R, D'Ambrosio D, Corpina RA, Schoenherr CJ, Feeley K, Yu PB, Yancopoulos GD, Murphy AJ, Economides AN. Hatsell SJ, et al. Among authors: yu pb. Sci Transl Med. 2015 Sep 2;7(303):303ra137. doi: 10.1126/scitranslmed.aac4358. Sci Transl Med. 2015. PMID: 26333933 Free PMC article.
Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification.
Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Dey D, et al. Among authors: yu pb. Sci Transl Med. 2016 Nov 23;8(366):366ra163. doi: 10.1126/scitranslmed.aaf1090. Sci Transl Med. 2016. PMID: 27881824 Free PMC article.
The traumatic bone: trauma-induced heterotopic ossification.
Dey D, Wheatley BM, Cholok D, Agarwal S, Yu PB, Levi B, Davis TA. Dey D, et al. Among authors: yu pb. Transl Res. 2017 Aug;186:95-111. doi: 10.1016/j.trsl.2017.06.004. Epub 2017 Jun 15. Transl Res. 2017. PMID: 28668522 Free PMC article. Review.
Strategic Targeting of Multiple BMP Receptors Prevents Trauma-Induced Heterotopic Ossification.
Agarwal S, Loder SJ, Breuler C, Li J, Cholok D, Brownley C, Peterson J, Hsieh HH, Drake J, Ranganathan K, Niknafs YS, Xiao W, Li S, Kumar R, Tompkins R, Longaker MT, Davis TA, Yu PB, Mishina Y, Levi B. Agarwal S, et al. Among authors: yu pb. Mol Ther. 2017 Aug 2;25(8):1974-1987. doi: 10.1016/j.ymthe.2017.01.008. Epub 2017 Jul 15. Mol Ther. 2017. PMID: 28716575 Free PMC article.
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension.
Yung LM, Yang P, Joshi S, Augur ZM, Kim SSJ, Bocobo GA, Dinter T, Troncone L, Chen PS, McNeil ME, Southwood M, Poli de Frias S, Knopf J, Rosas IO, Sako D, Pearsall RS, Quisel JD, Li G, Kumar R, Yu PB. Yung LM, et al. Among authors: yu pb. Sci Transl Med. 2020 May 13;12(543):eaaz5660. doi: 10.1126/scitranslmed.aaz5660. Sci Transl Med. 2020. PMID: 32404506 Free PMC article.
127 results