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A repurposing approach identifies off-patent drugs with fungicidal cryptococcal activity, a common structural chemotype, and pharmacological properties relevant to the treatment of cryptococcosis.
Butts A, DiDone L, Koselny K, Baxter BK, Chabrier-Rosello Y, Wellington M, Krysan DJ. Butts A, et al. Among authors: wellington m. Eukaryot Cell. 2013 Feb;12(2):278-87. doi: 10.1128/EC.00314-12. Epub 2012 Dec 14. Eukaryot Cell. 2013. PMID: 23243064 Free PMC article.
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo.
Butts A, Koselny K, Chabrier-Roselló Y, Semighini CP, Brown JC, Wang X, Annadurai S, DiDone L, Tabroff J, Childers WE Jr, Abou-Gharbia M, Wellington M, Cardenas ME, Madhani HD, Heitman J, Krysan DJ. Butts A, et al. Among authors: wellington m. mBio. 2014 Feb 11;5(1):e00765-13. doi: 10.1128/mBio.00765-13. mBio. 2014. PMID: 24520056 Free PMC article.
Catching fire: Candida albicans, macrophages, and pyroptosis.
Krysan DJ, Sutterwala FS, Wellington M. Krysan DJ, et al. Among authors: wellington m. PLoS Pathog. 2014 Jun 26;10(6):e1004139. doi: 10.1371/journal.ppat.1004139. eCollection 2014 Jun. PLoS Pathog. 2014. PMID: 24967821 Free PMC article. No abstract available.
The Celecoxib Derivative AR-12 Has Broad-Spectrum Antifungal Activity In Vitro and Improves the Activity of Fluconazole in a Murine Model of Cryptococcosis.
Koselny K, Green J, DiDone L, Halterman JP, Fothergill AW, Wiederhold NP, Patterson TF, Cushion MT, Rappelye C, Wellington M, Krysan DJ. Koselny K, et al. Among authors: wellington m. Antimicrob Agents Chemother. 2016 Nov 21;60(12):7115-7127. doi: 10.1128/AAC.01061-16. Print 2016 Dec. Antimicrob Agents Chemother. 2016. PMID: 27645246 Free PMC article.
125 results