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An integrated and continuous downstream process for microbial virus-like particle vaccine biomanufacture.
Biotechnol Bioeng. 2022 Aug;119(8):2122-2133. doi: 10.1002/bit.28118. Epub 2022 May 10.
Biotechnol Bioeng. 2022.
PMID: 35478403
Free PMC article.
Virus-like particle preparation is improved by control over capsomere-DNA interactions during chromatographic purification.
Gerstweiler L, Bi J, Middelberg APJ.
Gerstweiler L, et al.
Biotechnol Bioeng. 2021 Apr;118(4):1707-1720. doi: 10.1002/bit.27687. Epub 2021 Feb 19.
Biotechnol Bioeng. 2021.
PMID: 33484156
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Comparative evaluation of integrated purification pathways for bacterial modular polyomavirus major capsid protein VP1 to produce virus-like particles using high throughput process technologies.
Gerstweiler L, Billakanti J, Bi J, Middelberg A.
Gerstweiler L, et al.
J Chromatogr A. 2021 Feb 22;1639:461924. doi: 10.1016/j.chroma.2021.461924. Epub 2021 Jan 21.
J Chromatogr A. 2021.
PMID: 33545579
Free PMC article.
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Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration.
Gerstweiler L, Billakanti J, Bi J, Middelberg APJ.
Gerstweiler L, et al.
J Chromatogr A. 2022 Mar 29;1667:462884. doi: 10.1016/j.chroma.2022.462884. Epub 2022 Feb 6.
J Chromatogr A. 2022.
PMID: 35182911
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Model based process optimization of an industrial chromatographic process for separation of lactoferrin from bovine milk.
Gerstweiler L, Schad P, Trunzer T, Enghauser L, Mayr M, Billakanti J.
Gerstweiler L, et al.
J Chromatogr A. 2023 Nov 8;1710:464428. doi: 10.1016/j.chroma.2023.464428. Epub 2023 Oct 2.
J Chromatogr A. 2023.
PMID: 37797420
Free article.
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Experimental and molecular dynamics simulation studies on the physical properties of three HBc-VLP derivatives as nanoparticle protein vaccine candidates.
Luo H, Ma Y, Bi J, Li Z, Wang Y, Su Z, Gerstweiler L, Ren Y, Zhang S.
Luo H, et al. Among authors: gerstweiler l.
Vaccine. 2024 May 28:S0264-410X(24)00599-1. doi: 10.1016/j.vaccine.2024.05.040. Online ahead of print.
Vaccine. 2024.
PMID: 38811268
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