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ZIM, a Norbornene Derived from 4-Aminoantipyrine, Induces DNA Damage and Cell Death but in Association Reduces the Effect of Commercial Chemotherapeutics.
Oliveira RJ, da Silveira IOMF, das Neves SC, Mitsuyasu B, Martins AC, Berno C, Mohammad J, Raj H, de Araujo FHS, Hortelan CR, Machado L, da Silva Júnior EN, Vilela MLB, Nascimento VA, Beatriz A, da Silva Gomes R. Oliveira RJ, et al. Among authors: da silveira iomf. Chem Res Toxicol. 2023 Jan 16;36(1):66-82. doi: 10.1021/acs.chemrestox.2c00275. Epub 2022 Dec 22. Chem Res Toxicol. 2023. PMID: 36548215
Design, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype.
da Silveira IOMF, Moslaves ISB, Muller JAI, Hortelan CRW, Juliano Oliveira R, Okuyama TT, Fernandes J, Badenoch B, Janaína de Campos L, Almeida LD, Mohammad J, Martins ACF, Beatriz A, da Silva Júnior EN, Cristina Toffoli-Kadri M, da Silva Gomes R. da Silveira IOMF, et al. Bioorg Chem. 2022 Jul;124:105754. doi: 10.1016/j.bioorg.2022.105754. Epub 2022 Mar 26. Bioorg Chem. 2022. PMID: 35469631
Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics.
Oliveira RJ, da Cruz Leite Santos N, Pesarini JR, de Oliveira BC, Berno CR, de Araújo FHS, da Silveira IOMF, Nascimento RO, Brochado Antoniolli-Silva ACM, Duenhas Monreal AC, Beatriz A, de Lima DP, da Silva Gomes R. Oliveira RJ, et al. Among authors: da silveira iomf. Genet Mol Biol. 2018 Jan-Mar;41(1):154-166. doi: 10.1590/1678-4685-GMB-2017-0091. Epub 2018 Feb 19. Genet Mol Biol. 2018. PMID: 29473933 Free PMC article.
4-Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice.
Berno CR, Rós Bde T, da Silveira IO, Coelho HR, Antoniolli AC, Beatriz A, de Lima DP, Monreal AC, Sousa FG, da Silva Gomes R, Oliveira RJ. Berno CR, et al. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. doi: 10.1016/j.mrgentox.2016.05.009. Epub 2016 May 20. Mutat Res Genet Toxicol Environ Mutagen. 2016. PMID: 27402479 Free article.