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Design, synthesis and in vivo evaluation of 1,4-dioxo-2-butenyl aryl amine derivatives as a promising anti-inflammatory drug prototype.
da Silveira IOMF, Moslaves ISB, Muller JAI, Hortelan CRW, Juliano Oliveira R, Okuyama TT, Fernandes J, Badenoch B, Janaína de Campos L, Almeida LD, Mohammad J, Martins ACF, Beatriz A, da Silva Júnior EN, Cristina Toffoli-Kadri M, da Silva Gomes R. da Silveira IOMF, et al. Among authors: da silva gomes r, da silva junior en. Bioorg Chem. 2022 Jul;124:105754. doi: 10.1016/j.bioorg.2022.105754. Epub 2022 Mar 26. Bioorg Chem. 2022. PMID: 35469631
Design of hybrid molecules as antimycobacterial compounds: Synthesis of isoniazid-naphthoquinone derivatives and their activity against susceptible and resistant strains of Mycobacterium tuberculosis.
Reis WJ, Bozzi ÍAO, Ribeiro MF, Halicki PCB, Ferreira LA, Almeida da Silva PE, Ramos DF, de Simone CA, da Silva Júnior EN. Reis WJ, et al. Among authors: da silva junior en. Bioorg Med Chem. 2019 Sep 15;27(18):4143-4150. doi: 10.1016/j.bmc.2019.07.045. Epub 2019 Jul 27. Bioorg Med Chem. 2019. PMID: 31378595 Free article.
Strategies towards potent trypanocidal drugs: Application of Rh-catalyzed [2 + 2 + 2] cycloadditions, sulfonyl phthalide annulation and nitroalkene reactions for the synthesis of substituted quinones and their evaluation against Trypanosoma cruzi.
Wood JM, Satam NS, Almeida RG, Cristani VS, de Lima DP, Dantas-Pereira L, Salomão K, Menna-Barreto RFS, Namboothiri INN, Bower JF, da Silva Júnior EN. Wood JM, et al. Among authors: da silva junior en. Bioorg Med Chem. 2020 Aug 1;28(15):115565. doi: 10.1016/j.bmc.2020.115565. Epub 2020 May 30. Bioorg Med Chem. 2020. PMID: 32631558
Cathepsin K inhibitors based on 2-amino-1,3,4-oxadiazole derivatives.
Gontijo TB, Lima PS, Icimoto MY, Neves RL, de Alvarenga ÉC, Carmona AK, de Castro AA, Ramalho TC, da Silva Júnior EN, de Freitas RP. Gontijo TB, et al. Among authors: da silva junior en. Bioorg Chem. 2021 Apr;109:104662. doi: 10.1016/j.bioorg.2021.104662. Epub 2021 Jan 22. Bioorg Chem. 2021. PMID: 33626452
Synthesis and anti-Trypanosoma cruzi activity of naphthoquinone-containing triazoles: electrochemical studies on the effects of the quinoidal moiety.
Diogo EB, Dias GG, Rodrigues BL, Guimarães TT, Valença WO, Camara CA, de Oliveira RN, da Silva MG, Ferreira VF, de Paiva YG, Goulart MO, Menna-Barreto RF, de Castro SL, da Silva Júnior EN. Diogo EB, et al. Among authors: da silva junior en, da silva mg. Bioorg Med Chem. 2013 Nov 1;21(21):6337-48. doi: 10.1016/j.bmc.2013.08.055. Epub 2013 Sep 6. Bioorg Med Chem. 2013. PMID: 24074878 Free article.
On the synthesis of quinone-based BODIPY hybrids: New insights on antitumor activity and mechanism of action in cancer cells.
Gontijo TB, de Freitas RP, Emery FS, Pedrosa LF, Vieira Neto JB, Cavalcanti BC, Pessoa C, King A, de Moliner F, Vendrell M, da Silva Júnior EN. Gontijo TB, et al. Among authors: da silva junior en. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4446-4456. doi: 10.1016/j.bmcl.2017.08.007. Epub 2017 Aug 4. Bioorg Med Chem Lett. 2017. PMID: 28818447 Free article.
84 results