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The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses.
Melderis S, Warkotsch MT, Dang J, Hagenstein J, Ehnold LI, Herrnstadt GR, Niehus CB, Feindt FC, Kylies D, Puelles VG, Berasain C, Avila MA, Neumann K, Tiegs G, Huber TB, Tharaux PL, Steinmetz OM. Melderis S, et al. Among authors: steinmetz om. J Autoimmun. 2022 May;129:102829. doi: 10.1016/j.jaut.2022.102829. Epub 2022 Apr 22. J Autoimmun. 2022. PMID: 35468361
CXCR3 mediates renal Th1 and Th17 immune response in murine lupus nephritis.
Steinmetz OM, Turner JE, Paust HJ, Lindner M, Peters A, Heiss K, Velden J, Hopfer H, Fehr S, Krieger T, Meyer-Schwesinger C, Meyer TN, Helmchen U, Mittrücker HW, Stahl RA, Panzer U. Steinmetz OM, et al. J Immunol. 2009 Oct 1;183(7):4693-704. doi: 10.4049/jimmunol.0802626. Epub 2009 Sep 4. J Immunol. 2009. PMID: 19734217
CCR6 recruits regulatory T cells and Th17 cells to the kidney in glomerulonephritis.
Turner JE, Paust HJ, Steinmetz OM, Peters A, Riedel JH, Erhardt A, Wegscheid C, Velden J, Fehr S, Mittrücker HW, Tiegs G, Stahl RA, Panzer U. Turner JE, et al. Among authors: steinmetz om. J Am Soc Nephrol. 2010 Jun;21(6):974-85. doi: 10.1681/ASN.2009070741. Epub 2010 Mar 18. J Am Soc Nephrol. 2010. PMID: 20299360 Free PMC article.
Immature renal dendritic cells recruit regulatory CXCR6(+) invariant natural killer T cells to attenuate crescentic GN.
Riedel JH, Paust HJ, Turner JE, Tittel AP, Krebs C, Disteldorf E, Wegscheid C, Tiegs G, Velden J, Mittrücker HW, Garbi N, Stahl RA, Steinmetz OM, Kurts C, Panzer U. Riedel JH, et al. Among authors: steinmetz om. J Am Soc Nephrol. 2012 Dec;23(12):1987-2000. doi: 10.1681/ASN.2012040394. Epub 2012 Nov 8. J Am Soc Nephrol. 2012. PMID: 23138484 Free PMC article.
Stat3 programs Th17-specific regulatory T cells to control GN.
Kluger MA, Luig M, Wegscheid C, Goerke B, Paust HJ, Brix SR, Yan I, Mittrücker HW, Hagl B, Renner ED, Tiegs G, Wiech T, Stahl RA, Panzer U, Steinmetz OM. Kluger MA, et al. Among authors: steinmetz om. J Am Soc Nephrol. 2014 Jun;25(6):1291-302. doi: 10.1681/ASN.2013080904. Epub 2014 Feb 7. J Am Soc Nephrol. 2014. PMID: 24511136 Free PMC article.
Function of the Th17/interleukin-17A immune response in murine lupus nephritis.
Schmidt T, Paust HJ, Krebs CF, Turner JE, Kaffke A, Bennstein SB, Koyro T, Peters A, Velden J, Hünemörder S, Haag F, Steinmetz OM, Mittrücker HW, Stahl RA, Panzer U. Schmidt T, et al. Among authors: steinmetz om. Arthritis Rheumatol. 2015 Feb;67(2):475-87. doi: 10.1002/art.38955. Arthritis Rheumatol. 2015. PMID: 25385550
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