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The Amphiregulin/EGFR axis protects from lupus nephritis via downregulation of pathogenic CD4+ T helper cell responses.
Melderis S, Warkotsch MT, Dang J, Hagenstein J, Ehnold LI, Herrnstadt GR, Niehus CB, Feindt FC, Kylies D, Puelles VG, Berasain C, Avila MA, Neumann K, Tiegs G, Huber TB, Tharaux PL, Steinmetz OM. Melderis S, et al. Among authors: puelles vg. J Autoimmun. 2022 May;129:102829. doi: 10.1016/j.jaut.2022.102829. Epub 2022 Apr 22. J Autoimmun. 2022. PMID: 35468361
The tetraspanin CD9 controls migration and proliferation of parietal epithelial cells and glomerular disease progression.
Lazareth H, Henique C, Lenoir O, Puelles VG, Flamant M, Bollée G, Fligny C, Camus M, Guyonnet L, Millien C, Gaillard F, Chipont A, Robin B, Fabrega S, Dhaun N, Camerer E, Kretz O, Grahammer F, Braun F, Huber TB, Nochy D, Mandet C, Bruneval P, Mesnard L, Thervet E, Karras A, Le Naour F, Rubinstein E, Boucheix C, Alexandrou A, Moeller MJ, Bouzigues C, Tharaux PL. Lazareth H, et al. Among authors: puelles vg. Nat Commun. 2019 Jul 24;10(1):3303. doi: 10.1038/s41467-019-11013-2. Nat Commun. 2019. PMID: 31341160 Free PMC article.
Dysregulated mesenchymal PDGFR-β drives kidney fibrosis.
Buhl EM, Djudjaj S, Klinkhammer BM, Ermert K, Puelles VG, Lindenmeyer MT, Cohen CD, He C, Borkham-Kamphorst E, Weiskirchen R, Denecke B, Trairatphisan P, Saez-Rodriguez J, Huber TB, Olson LE, Floege J, Boor P. Buhl EM, et al. Among authors: puelles vg. EMBO Mol Med. 2020 Mar 6;12(3):e11021. doi: 10.15252/emmm.201911021. Epub 2020 Jan 14. EMBO Mol Med. 2020. PMID: 31943786 Free PMC article.
Multiorgan and Renal Tropism of SARS-CoV-2.
Puelles VG, Lütgehetmann M, Lindenmeyer MT, Sperhake JP, Wong MN, Allweiss L, Chilla S, Heinemann A, Wanner N, Liu S, Braun F, Lu S, Pfefferle S, Schröder AS, Edler C, Gross O, Glatzel M, Wichmann D, Wiech T, Kluge S, Pueschel K, Aepfelbacher M, Huber TB. Puelles VG, et al. N Engl J Med. 2020 Aug 6;383(6):590-592. doi: 10.1056/NEJMc2011400. Epub 2020 May 13. N Engl J Med. 2020. PMID: 32402155 Free PMC article. No abstract available.
Interleukin-9 protects from early podocyte injury and progressive glomerulosclerosis in Adriamycin-induced nephropathy.
Xiong T, Attar M, Gnirck AC, Wunderlich M, Becker M, Rickassel C, Puelles VG, Meyer-Schwesinger C, Wiech T, Nies JF, Divivier M, Fuchs T, Schulze Zur Wiesch J, Taipaleenmäki H, Hoxha E, Wirtz S, Huber TB, Panzer U, Turner JE. Xiong T, et al. Among authors: puelles vg. Kidney Int. 2020 Sep;98(3):615-629. doi: 10.1016/j.kint.2020.04.036. Epub 2020 May 21. Kidney Int. 2020. PMID: 32446933
Clonal expansion and activation of tissue-resident memory-like Th17 cells expressing GM-CSF in the lungs of severe COVID-19 patients.
Zhao Y, Kilian C, Turner JE, Bosurgi L, Roedl K, Bartsch P, Gnirck AC, Cortesi F, Schultheiß C, Hellmig M, Enk LUB, Hausmann F, Borchers A, Wong MN, Paust HJ, Siracusa F, Scheibel N, Herrmann M, Rosati E, Bacher P, Kylies D, Jarczak D, Lütgehetmann M, Pfefferle S, Steurer S, Zur-Wiesch JS, Puelles VG, Sperhake JP, Addo MM, Lohse AW, Binder M, Huber S, Huber TB, Kluge S, Bonn S, Panzer U, Gagliani N, Krebs CF. Zhao Y, et al. Among authors: puelles vg. Sci Immunol. 2021 Feb 23;6(56):eabf6692. doi: 10.1126/sciimmunol.abf6692. Sci Immunol. 2021. PMID: 33622974 Free PMC article.
Pro-cachectic factors link experimental and human chronic kidney disease to skeletal muscle wasting programs.
Solagna F, Tezze C, Lindenmeyer MT, Lu S, Wu G, Liu S, Zhao Y, Mitchell R, Meyer C, Omairi S, Kilic T, Paolini A, Ritvos O, Pasternack A, Matsakas A, Kylies D, Wiesch JSZ, Turner JE, Wanner N, Nair V, Eichinger F, Menon R, Martin IV, Klinkhammer BM, Hoxha E, Cohen CD, Tharaux PL, Boor P, Ostendorf T, Kretzler M, Sandri M, Kretz O, Puelles VG, Patel K, Huber TB. Solagna F, et al. Among authors: puelles vg. J Clin Invest. 2021 Jun 1;131(11):e135821. doi: 10.1172/JCI135821. J Clin Invest. 2021. PMID: 34060483 Free PMC article.
83 results