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A factor VIIIa-mimetic bispecific antibody, Mim8, ameliorates bleeding upon severe vascular challenge in hemophilia A mice.
Østergaard H, Lund J, Greisen PJ, Kjellev S, Henriksen A, Lorenzen N, Johansson E, Røder G, Rasch MG, Johnsen LB, Egebjerg T, Lund S, Rahbek-Nielsen H, Gandhi PS, Lamberth K, Loftager M, Andersen LM, Bonde AC, Stavenuiter F, Madsen DE, Li X, Holm TL, Ley CD, Thygesen P, Zhu H, Zhou R, Thorn K, Yang Z, Hermit MB, Bjelke JR, Hansen BG, Hilden I. Østergaard H, et al. Among authors: thygesen p. Blood. 2021 Oct 7;138(14):1258-1268. doi: 10.1182/blood.2020010331. Blood. 2021. PMID: 34077951 Free PMC article.
Antibody-Mediated Neutralization of uPA Proteolytic Function Reduces Disease Progression in Mouse Arthritis Models.
Almholt K, Hebsgaard JB, Nansen A, Andersson C, Pass J, Rønø B, Thygesen P, Pelzer H, Loftager M, Lund IK, Høyer-Hansen G, Frisch T, Jensen CH, Otte KS, Søe NH, Bartels EM, Andersen M, Bliddal H, Usher PA. Almholt K, et al. Among authors: thygesen p. J Immunol. 2018 Feb 1;200(3):957-965. doi: 10.4049/jimmunol.1701317. Epub 2017 Dec 27. J Immunol. 2018. PMID: 29282305
The kidneys play a central role in the clearance of rhGH in rats.
Vestergaard B, Thygesen P, Kreilgaard M, Fels JJ, Lykkesfeldt J, Agersø H. Vestergaard B, et al. Among authors: thygesen p. Eur J Pharm Sci. 2016 Apr 30;86:29-33. doi: 10.1016/j.ejps.2016.02.019. Epub 2016 Mar 2. Eur J Pharm Sci. 2016. PMID: 26946443
Towards a Göttingen minipig model of adult onset growth hormone deficiency: evaluation of stereotactic electrocoagulation method.
Ørstrup LH, Tvilling L, Orlowski D, Zaer H, Bjarkam CR, von Voss P, Andersen PS, Christoffersen BØ, Hedemann Sørensen JC, Laursen T, Thygesen P, Lykkesfeldt J, Glud AN. Ørstrup LH, et al. Among authors: thygesen p. Heliyon. 2019 Nov 28;5(11):e02892. doi: 10.1016/j.heliyon.2019.e02892. eCollection 2019 Nov. Heliyon. 2019. PMID: 31844758 Free PMC article.
Long-Acting Human Growth Hormone Analogue by Noncovalent Albumin Binding.
Ramírez-Andersen HS, Behrens C, Buchardt J, Fels JJ, Folkesson CG, Jianhe C, Nørskov-Lauritsen L, Nielsen PF, Reslow M, Rischel C, Su J, Thygesen P, Wiberg C, Zhao X, Wenjuan X, Johansen NL. Ramírez-Andersen HS, et al. Among authors: thygesen p. Bioconjug Chem. 2018 Sep 19;29(9):3129-3143. doi: 10.1021/acs.bioconjchem.8b00463. Epub 2018 Aug 31. Bioconjug Chem. 2018. PMID: 30168709
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