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GSK1702934A and M085 directly activate TRPC6 via a mechanism of stimulating the extracellular cavity formed by the pore helix and transmembrane helix S6.
Yang PL, Li XH, Wang J, Ma XF, Zhou BY, Jiao YF, Wang WH, Cao P, Zhu MX, Li PW, Xiao ZH, Li CZ, Guo CR, Lei YT, Yu Y. Yang PL, et al. Among authors: wang j, wang wh. J Biol Chem. 2021 Oct;297(4):101125. doi: 10.1016/j.jbc.2021.101125. Epub 2021 Aug 28. J Biol Chem. 2021. PMID: 34461094 Free PMC article.
Vanilloid agonist-mediated activation of TRPV1 channels requires coordinated movement of the S1-S4 bundle rather than a quiescent state.
Sun MY, Zhang X, Yu PC, Liu D, Yang Y, Cui WW, Yang XN, Lei YT, Li XH, Wang WH, Cao P, Wang HS, Zhu MX, Li CZ, Wang R, Fan YZ, Yu Y. Sun MY, et al. Among authors: wang hs, wang wh, wang r. Sci Bull (Beijing). 2022 May 30;67(10):1062-1076. doi: 10.1016/j.scib.2022.02.016. Epub 2022 Mar 1. Sci Bull (Beijing). 2022. PMID: 36546250 Free article.
1,720 results