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Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma.
Wong J, Gruber E, Maher B, Waltham M, Sabouri-Thompson Z, Jong I, Luong Q, Levy S, Kumar B, Brasacchio D, Jia W, So J, Skinner H, Lewis A, Hogg SJ, Vervoort S, DiCorleto C, Uhe M, Gamgee J, Opat S, Gregory GP, Polekhina G, Reynolds J, Hawkes EA, Kailainathan G, Gasiorowski R, Kats LM, Shortt J. Wong J, et al. Among authors: gruber e. Leukemia. 2022 Jun;36(6):1654-1665. doi: 10.1038/s41375-022-01571-8. Epub 2022 Apr 22. Leukemia. 2022. PMID: 35459873 Free PMC article. Clinical Trial.
IL-15 Preconditioning Augments CAR T Cell Responses to Checkpoint Blockade for Improved Treatment of Solid Tumors.
Giuffrida L, Sek K, Henderson MA, House IG, Lai J, Chen AXY, Todd KL, Petley EV, Mardiana S, Todorovski I, Gruber E, Kelly MJ, Solomon BJ, Vervoort SJ, Johnstone RW, Parish IA, Neeson PJ, Kats LM, Darcy PK, Beavis PA. Giuffrida L, et al. Among authors: gruber e. Mol Ther. 2020 Nov 4;28(11):2379-2393. doi: 10.1016/j.ymthe.2020.07.018. Epub 2020 Jul 21. Mol Ther. 2020. PMID: 32735774 Free PMC article.
Serine Biosynthesis Is a Metabolic Vulnerability in FLT3-ITD-Driven Acute Myeloid Leukemia.
Bjelosevic S, Gruber E, Newbold A, Shembrey C, Devlin JR, Hogg SJ, Kats L, Todorovski I, Fan Z, Abrehart TC, Pomilio G, Wei A, Gregory GP, Vervoort SJ, Brown KK, Johnstone RW. Bjelosevic S, et al. Among authors: gruber e. Cancer Discov. 2021 Jun;11(6):1582-1599. doi: 10.1158/2159-8290.CD-20-0738. Epub 2021 Jan 12. Cancer Discov. 2021. PMID: 33436370
Inhibition of pyrimidine biosynthesis targets protein translation in acute myeloid leukemia.
So J, Lewis AC, Smith LK, Stanley K, Franich R, Yoannidis D, Pijpers L, Dominguez P, Hogg SJ, Vervoort SJ, Brown FC, Johnstone RW, McDonald G, Ulanet DB, Murtie J, Gruber E, Kats LM. So J, et al. Among authors: gruber e. EMBO Mol Med. 2022 Jul 7;14(7):e15203. doi: 10.15252/emmm.202115203. Epub 2022 May 6. EMBO Mol Med. 2022. PMID: 35514210 Free PMC article.
Inhibition of mutant IDH1 promotes cycling of acute myeloid leukemia stem cells.
Gruber E, So J, Lewis AC, Franich R, Cole R, Martelotto LG, Rogers AJ, Vidacs E, Fraser P, Stanley K, Jones L, Trigos A, Thio N, Li J, Nicolay B, Daigle S, Tron AE, Hyer ML, Shortt J, Johnstone RW, Kats LM. Gruber E, et al. Cell Rep. 2022 Aug 16;40(7):111182. doi: 10.1016/j.celrep.2022.111182. Cell Rep. 2022. PMID: 35977494 Free article.
Rationally designed chimeric PI3K-BET bromodomain inhibitors elicit curative responses in MYC-driven lymphoma.
Oh DH, Ma X, Hogg SJ, He J, Kearney C, Brasacchio D, Susanto O, Maher B, Jennings IG, Newbold A, Fraser P, Gruber E, Kats LM, Gregory GP, Johnstone RW, Thompson PE, Shortt J. Oh DH, et al. Among authors: gruber e. Proc Natl Acad Sci U S A. 2023 Sep 5;120(36):e2306414120. doi: 10.1073/pnas.2306414120. Epub 2023 Aug 29. Proc Natl Acad Sci U S A. 2023. PMID: 37643213 Free PMC article.
RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells.
Tullett KM, Tan PS, Park HY, Schittenhelm RB, Michael N, Li R, Policheni AN, Gruber E, Huang C, Fulcher AJ, Danne JC, Czabotar PE, Wakim LM, Mintern JD, Ramm G, Radford KJ, Caminschi I, O'Keeffe M, Villadangos JA, Wright MD, Blewitt ME, Heath WR, Shortman K, Purcell AW, Nicola NA, Zhang JG, Lahoud MH. Tullett KM, et al. Among authors: gruber e. Elife. 2020 Dec 2;9:e63452. doi: 10.7554/eLife.63452. Elife. 2020. PMID: 33264090 Free PMC article.
272 results