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New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer.
Tawfik HO, El-Hamaky AA, El-Bastawissy EA, Shcherbakov KA, Veselovsky AV, Gladilina YA, Zhdanov DD, El-Hamamsy MH. Tawfik HO, et al. Pharmaceuticals (Basel). 2022 Apr 14;15(4):481. doi: 10.3390/ph15040481. Pharmaceuticals (Basel). 2022. PMID: 35455478 Free PMC article.
Discovery of new symmetrical and asymmetrical nitrile-containing 1,4-dihydropyridine derivatives as dual kinases and P-glycoprotein inhibitors: synthesis, in vitro assays, and in silico studies.
Saad MH, El-Moselhy TF, S El-Din N, Mehany ABM, Belal A, Abourehab MAS, Tawfik HO, El-Hamamsy MH. Saad MH, et al. Among authors: tawfik ho. J Enzyme Inhib Med Chem. 2022 Dec;37(1):2489-2511. doi: 10.1080/14756366.2022.2120478. J Enzyme Inhib Med Chem. 2022. PMID: 36093880 Free PMC article.
Ligand-Based Design on the Dog-Bone-Shaped BIBR1532 Pharmacophoric Features and Synthesis of Novel Analogues as Promising Telomerase Inhibitors with In Vitro and In Vivo Evaluations.
Al-Karmalawy AA, Nafie MS, Shaldam MA, Elmaaty AA, Antar SA, El-Hamaky AA, Saleh MA, Elkamhawy A, Tawfik HO. Al-Karmalawy AA, et al. Among authors: tawfik ho. J Med Chem. 2023 Jan 12;66(1):777-792. doi: 10.1021/acs.jmedchem.2c01668. Epub 2022 Dec 16. J Med Chem. 2023. PMID: 36525642
37 results