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Pan-Phosphodiesterase Inhibitors Attenuate TGF-β-Induced Pro-Fibrotic Phenotype in Alveolar Epithelial Type II Cells by Downregulating Smad-2 Phosphorylation.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ferreira B, Koczurkiewicz-Adamczyk P, Pękala E, Wyska E, Pociecha K, Gosens R. Wójcik-Pszczoła K, et al. Among authors: gosens r. Pharmaceuticals (Basel). 2022 Mar 30;15(4):423. doi: 10.3390/ph15040423. Pharmaceuticals (Basel). 2022. PMID: 35455420 Free PMC article.
Novel phosphodiesterases inhibitors from the group of purine-2,6-dione derivatives as potent modulators of airway smooth muscle cell remodelling.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ellen E, Świerczek A, Pociecha K, Koczurkiewicz P, Piska K, Gawędzka A, Wyska E, Knapik-Czajka M, Pękala E, Gosens R. Wójcik-Pszczoła K, et al. Among authors: gosens r. Eur J Pharmacol. 2019 Dec 15;865:172779. doi: 10.1016/j.ejphar.2019.172779. Epub 2019 Nov 6. Eur J Pharmacol. 2019. PMID: 31705904
A Novel, Pan-PDE Inhibitor Exerts Anti-Fibrotic Effects in Human Lung Fibroblasts via Inhibition of TGF-β Signaling and Activation of cAMP/PKA Signaling.
Wójcik-Pszczoła K, Chłoń-Rzepa G, Jankowska A, Ślusarczyk M, Ferdek PE, Kusiak AA, Świerczek A, Pociecha K, Koczurkiewicz-Adamczyk P, Wyska E, Pękala E, Gosens R. Wójcik-Pszczoła K, et al. Among authors: gosens r. Int J Mol Sci. 2020 Jun 3;21(11):4008. doi: 10.3390/ijms21114008. Int J Mol Sci. 2020. PMID: 32503342 Free PMC article.
Synthesis and in vitro evaluation of anti-inflammatory, antioxidant, and anti-fibrotic effects of new 8-aminopurine-2,6-dione-based phosphodiesterase inhibitors as promising anti-asthmatic agents.
Wójcik-Pszczoła K, Jankowska A, Ślusarczyk M, Jakieła B, Plutecka H, Pociecha K, Świerczek A, Popiół J, Koczurkiewicz-Adamczyk P, Wyska E, Pękala E, Gosens R, Chłoń-Rzepa G. Wójcik-Pszczoła K, et al. Among authors: gosens r. Bioorg Chem. 2021 Dec;117:105409. doi: 10.1016/j.bioorg.2021.105409. Epub 2021 Oct 16. Bioorg Chem. 2021. PMID: 34749117 Free article.
Inhaled pan-phosphodiesterase inhibitors ameliorate ovalbumin-induced airway inflammation and remodeling in murine model of allergic asthma.
Wójcik-Pszczoła K, Pociecha K, Chłoń-Rzepa G, Zadrożna M, Nowak B, Plutecka H, Koczurkiewicz-Adamczyk P, Przejczowska-Pomierny K, Pękala E, Gosens R, Wyska E. Wójcik-Pszczoła K, et al. Among authors: gosens r. Int Immunopharmacol. 2023 Jun;119:110264. doi: 10.1016/j.intimp.2023.110264. Epub 2023 May 7. Int Immunopharmacol. 2023. PMID: 37159965 Free article.
191 results