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Inhalation of the prodrug PI3K inhibitor CL27c improves lung function in asthma and fibrosis.
Campa CC, Silva RL, Margaria JP, Pirali T, Mattos MS, Kraemer LR, Reis DC, Grosa G, Copperi F, Dalmarco EM, Lima-Júnior RCP, Aprile S, Sala V, Dal Bello F, Prado DS, Alves-Filho JC, Medana C, Cassali GD, Tron GC, Teixeira MM, Ciraolo E, Russo RC, Hirsch E. Campa CC, et al. Nat Commun. 2018 Dec 12;9(1):5232. doi: 10.1038/s41467-018-07698-6. Nat Commun. 2018. PMID: 30542075 Free PMC article.
Targeting neutrophils in sepsis.
Sônego F, Alves-Filho JC, Cunha FQ. Sônego F, et al. Expert Rev Clin Immunol. 2014 Aug;10(8):1019-28. doi: 10.1586/1744666X.2014.922876. Epub 2014 May 28. Expert Rev Clin Immunol. 2014. PMID: 24867165 Review.
Gasdermin D inhibition prevents multiple organ dysfunction during sepsis by blocking NET formation.
Silva CMS, Wanderley CWS, Veras FP, Sonego F, Nascimento DC, Gonçalves AV, Martins TV, Cólon DF, Borges VF, Brauer VS, Damasceno LEA, Silva KP, Toller-Kawahisa JE, Batah SS, Souza ALJ, Monteiro VS, Oliveira AER, Donate PB, Zoppi D, Borges MC, Almeida F, Nakaya HI, Fabro AT, Cunha TM, Alves-Filho JC, Zamboni DS, Cunha FQ. Silva CMS, et al. Blood. 2021 Dec 23;138(25):2702-2713. doi: 10.1182/blood.2021011525. Blood. 2021. PMID: 34407544 Free PMC article.
PD-1/PD-L1 Inhibition Enhances Chemotherapy-Induced Neuropathic Pain by Suppressing Neuroimmune Antinociceptive Signaling.
Wanderley CWS, Maganin AGM, Adjafre B, Mendes AS, Silva CEA, Quadros AU, Luiz JPM, Silva CMS, Silva NR, Oliveira FFB, Gomes FIF, Restrepo JLJ, Speck-Hernandez CA, Turaça F, Silva GVL, Pigatto GR, Nakaya HI, Mota JM, Barroso-Sousa R, Alves-Filho JC, Cunha TM, Cunha FQ. Wanderley CWS, et al. Cancer Immunol Res. 2022 Nov 2;10(11):1299-1308. doi: 10.1158/2326-6066.CIR-22-0003. Cancer Immunol Res. 2022. PMID: 36083496
Paediatric sepsis survivors are resistant to sepsis-induced long-term immune dysfunction.
Colón DF, Wanderley CW, Turato WM, Borges VF, Franchin M, Castanheira FVS, Nascimento D, Prado D, Haruo Fernandes de Lima M, Volpon LC, Kavaguti SK, Carlotti AP, Carmona F, Franklin BS, Cunha TM, Alves-Filho JC, Cunha FQ. Colón DF, et al. Among authors: alves filho jc. Br J Pharmacol. 2024 Apr;181(8):1308-1323. doi: 10.1111/bph.16286. Epub 2024 Jan 11. Br J Pharmacol. 2024. PMID: 37990806
Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis.
Czaikoski PG, Mota JM, Nascimento DC, Sônego F, Castanheira FV, Melo PH, Scortegagna GT, Silva RL, Barroso-Sousa R, Souto FO, Pazin-Filho A, Figueiredo F, Alves-Filho JC, Cunha FQ. Czaikoski PG, et al. PLoS One. 2016 Feb 5;11(2):e0148142. doi: 10.1371/journal.pone.0148142. eCollection 2016. PLoS One. 2016. PMID: 26849138 Free PMC article.
Paradoxical Roles of the Neutrophil in Sepsis: Protective and Deleterious.
Sônego F, Castanheira FV, Ferreira RG, Kanashiro A, Leite CA, Nascimento DC, Colón DF, Borges Vde F, Alves-Filho JC, Cunha FQ. Sônego F, et al. Front Immunol. 2016 Apr 26;7:155. doi: 10.3389/fimmu.2016.00155. eCollection 2016. Front Immunol. 2016. PMID: 27199981 Free PMC article. Review.
222 results