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A Polynesian-specific copy number variant encompassing the MICA gene associates with gout.
Wang K, Cadzow M, Bixley M, Leask MP, Merriman ME, Yang Q, Li Z, Takei R, Phipps-Green A, Major TJ, Topless R, Dalbeth N, King F, Murphy R, Stamp LK, de Zoysa J, Wang Z, Shi Y, Merriman TR. Wang K, et al. Among authors: murphy r. Hum Mol Genet. 2022 Oct 28;31(21):3757-3768. doi: 10.1093/hmg/ddac094. Hum Mol Genet. 2022. PMID: 35451026 Free PMC article.
Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood".
Major TJ, Krishnan M, Topless RK, Dewes O, Thompson J, Zoysa J, Stamp LK, Dalbeth N, Deka R, Weeks DE, Minster RL, Wilcox P, Grattan D, Shepherd PR, Shelling AN, Murphy R, Merriman TR. Major TJ, et al. Among authors: murphy r. Int J Obes (Lond). 2018 Jul;42(7):1389-1391. doi: 10.1038/s41366-018-0025-1. Epub 2018 Mar 6. Int J Obes (Lond). 2018. PMID: 29511321 Free PMC article. No abstract available.
Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Māori and Pacific (Polynesian) people living in Aotearoa/New Zealand.
Krishnan M, Major TJ, Topless RK, Dewes O, Yu L, Thompson JMD, McCowan L, de Zoysa J, Stamp LK, Dalbeth N, Harré Hindmarsh J, Rapana N, Deka R, Eng WWH, Weeks DE, Minster RL, McGarvey ST, Viali S, Naseri T, Sefuiva Reupena M, Wilcox P, Grattan D, Shepherd PR, Shelling AN, Murphy R, Merriman TR. Krishnan M, et al. Among authors: murphy r. Diabetologia. 2018 Jul;61(7):1603-1613. doi: 10.1007/s00125-018-4623-1. Epub 2018 May 2. Diabetologia. 2018. PMID: 29721634 Free PMC article.
The Māori and Pacific specific CREBRF variant and adult height.
Metcalfe LK, Krishnan M, Turner N, Yaghootkar H, Merry TL, Dewes O, Hindmarsh JH, De Zoysa J, Dalbeth N, Stamp LK, Merriman TR, Smith G, Shepherd P, Murphy R. Metcalfe LK, et al. Among authors: murphy r. Int J Obes (Lond). 2020 Mar;44(3):748-752. doi: 10.1038/s41366-019-0437-6. Epub 2019 Sep 22. Int J Obes (Lond). 2020. PMID: 31543511
Randomised cross-over trial of vildagliptin and pioglitazone as add-on therapy in patients with type 2 diabetes: predicting Which One is Right Here (WORTH) study protocol.
Yeu RQ, Brandon R, Jiang Y, Griffiths D, Smallman K, Moffitt A, Doherty G, Paul R, Harré Hindmarsh J, Merriman TR, Macaskill-Smith K, Orr-Walker B, Murphy R. Yeu RQ, et al. Among authors: murphy r. BMJ Open. 2020 Sep 1;10(9):e036518. doi: 10.1136/bmjopen-2019-036518. BMJ Open. 2020. PMID: 32873667 Free PMC article.
The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.
Burden HJ, Adams S, Kulatea B, Wright-McNaughton M, Sword D, Ormsbee JJ, Watene-O'Sullivan C, Merriman TR, Knopp JL, Chase JG, Krebs JD, Hall RM, Plank LD, Murphy R, Shepherd PR, Merry TL. Burden HJ, et al. Among authors: murphy r. Diabetologia. 2021 Dec;64(12):2779-2789. doi: 10.1007/s00125-021-05552-x. Epub 2021 Aug 21. Diabetologia. 2021. PMID: 34417843
Mid-pass whole genome sequencing enables biomedical genetic studies of diverse populations.
Emde AK, Phipps-Green A, Cadzow M, Gallagher CS, Major TJ, Merriman ME, Topless RK, Takei R, Dalbeth N, Murphy R, Stamp LK, de Zoysa J, Wilcox PL, Fox K, Wasik KA, Merriman TR, Castel SE. Emde AK, et al. Among authors: murphy r. BMC Genomics. 2021 Nov 1;22(1):666. doi: 10.1186/s12864-021-07949-9. BMC Genomics. 2021. PMID: 34719381 Free PMC article.
4,606 results