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Microfluidic Squeezing Enables MHC Class I Antigen Presentation by Diverse Immune Cells to Elicit CD8+ T Cell Responses with Antitumor Activity.
Booty MG, Hlavaty KA, Stockmann A, Ozay EI, Smith C, Tian L, How E, Subramanya D, Venkitaraman A, Yee C, Pryor O, Volk K, Blagovic K, Vicente-Suarez I, Yarar D, Myint M, Merino A, Chow J, Abdeljawad T, An H, Liu S, Mao S, Heimann M, Talarico L, Jacques MK, Chong E, Pomerance L, Gonzalez JT, von Andrian UH, Jensen KF, Langer R, Knoetgen H, Trumpfheller C, Umaña P, Bernstein H, Sharei A, Loughhead SM. Booty MG, et al. Among authors: sharei a. J Immunol. 2022 Feb 15;208(4):929-940. doi: 10.4049/jimmunol.2100656. Epub 2022 Jan 28. J Immunol. 2022. PMID: 35091434 Free PMC article.
Engineered red blood cells (activating antigen carriers) drive potent T cell responses and tumor regression in mice.
Blagovic K, Smith CK, Ramakrishnan A, Moore L, Soto DR, Thompson Z, Stockmann AP, Kruszelnicki S, Thakkar A, Murray J, Torres S, Wondimagegnhu B, Yi R, Dadgar M, Paracha AM, Page C, Clear L, Chaudhry OA, Myint M, Bridgen DT, Gilbert JB, Seidl KJ, Sharei A, Loughhead S, Bernstein H, Yarar D. Blagovic K, et al. Among authors: sharei a. Front Immunol. 2022 Oct 3;13:1015585. doi: 10.3389/fimmu.2022.1015585. eCollection 2022. Front Immunol. 2022. PMID: 36263022 Free PMC article.
Cell engineering with microfluidic squeezing preserves functionality of primary immune cells in vivo.
DiTommaso T, Cole JM, Cassereau L, Buggé JA, Hanson JLS, Bridgen DT, Stokes BD, Loughhead SM, Beutel BA, Gilbert JB, Nussbaum K, Sorrentino A, Toggweiler J, Schmidt T, Gyuelveszi G, Bernstein H, Sharei A. DiTommaso T, et al. Among authors: sharei a. Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10907-E10914. doi: 10.1073/pnas.1809671115. Epub 2018 Oct 31. Proc Natl Acad Sci U S A. 2018. PMID: 30381459 Free PMC article.
Microfluidics-based assessment of cell deformability.
Adamo A, Sharei A, Adamo L, Lee B, Mao S, Jensen KF. Adamo A, et al. Among authors: sharei a. Anal Chem. 2012 Aug 7;84(15):6438-43. doi: 10.1021/ac300264v. Epub 2012 Jul 10. Anal Chem. 2012. PMID: 22746217 Free PMC article.
Ex vivo cytosolic delivery of functional macromolecules to immune cells.
Sharei A, Trifonova R, Jhunjhunwala S, Hartoularos GC, Eyerman AT, Lytton-Jean A, Angin M, Sharma S, Poceviciute R, Mao S, Heimann M, Liu S, Talkar T, Khan OF, Addo M, von Andrian UH, Anderson DG, Langer R, Lieberman J, Jensen KF. Sharei A, et al. PLoS One. 2015 Apr 13;10(4):e0118803. doi: 10.1371/journal.pone.0118803. eCollection 2015. PLoS One. 2015. PMID: 25875117 Free PMC article.
23 results