Siler SQ - Search Results

1

Considerations for Physiologically Based Modeling in Liver Disease: From Nonalcoholic Fatty Liver (NAFL) to Nonalcoholic Steatohepatitis (NASH).

Murphy WA, Adiwidjaja J, Sjöstedt N, Yang K, Beaudoin JJ, Spires J, Siler SQ, Neuhoff S, Brouwer KLR. Murphy WA, et al. Among authors: siler sq. Clin Pharmacol Ther. 2023 Feb;113(2):275-297. doi: 10.1002/cpt.2614. Epub 2022 Jun 2. Clin Pharmacol Ther. 2023. PMID: 35429164 Free PMC article. Review.

2

Mechanistic Modeling Reveals the Critical Knowledge Gaps in Bile Acid-Mediated DILI.

Woodhead JL, Yang K, Brouwer KL, Siler SQ, Stahl SH, Ambroso JL, Baker D, Watkins PB, Howell BA. Woodhead JL, et al. Among authors: siler sq. CPT Pharmacometrics Syst Pharmacol. 2014 Jul 9;3(7):e123. doi: 10.1038/psp.2014.21. CPT Pharmacometrics Syst Pharmacol. 2014. PMID: 25006780 Free PMC article.

3

Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.

Woodhead JL, Yang K, Siler SQ, Watkins PB, Brouwer KL, Barton HA, Howell BA. Woodhead JL, et al. Among authors: siler sq. Front Pharmacol. 2014 Nov 7;5:240. doi: 10.3389/fphar.2014.00240. eCollection 2014. Front Pharmacol. 2014. PMID: 25426072 Free PMC article.

4

Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.

Yang K, Guo C, Woodhead JL, St Claire RL 3rd, Watkins PB, Siler SQ, Howell BA, Brouwer KLR. Yang K, et al. Among authors: siler sq. J Pharm Sci. 2016 Feb;105(2):443-459. doi: 10.1016/j.xphs.2015.11.008. J Pharm Sci. 2016. PMID: 26869411 Free PMC article. Review.

5

Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.

Woodhead JL, Brock WJ, Roth SE, Shoaf SE, Brouwer KL, Church R, Grammatopoulos TN, Stiles L, Siler SQ, Howell BA, Mosedale M, Watkins PB, Shoda LK. Woodhead JL, et al. Among authors: siler sq. Toxicol Sci. 2017 Jan;155(1):61-74. doi: 10.1093/toxsci/kfw193. Epub 2016 Sep 21. Toxicol Sci. 2017. PMID: 27655350 Free PMC article.

6

Systems pharmacology modeling of drug-induced hyperbilirubinemia: Differentiating hepatotoxicity and inhibition of enzymes/transporters.

Yang K, Battista C, Woodhead JL, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Yang K, et al. Among authors: siler sq. Clin Pharmacol Ther. 2017 Apr;101(4):501-509. doi: 10.1002/cpt.619. Epub 2017 Feb 17. Clin Pharmacol Ther. 2017. PMID: 28074467 Free PMC article.

7

Refining Liver Safety Risk Assessment: Application of Mechanistic Modeling and Serum Biomarkers to Cimaglermin Alfa (GGF2) Clinical Trials.

Longo DM, Generaux GT, Howell BA, Siler SQ, Antoine DJ, Button D, Caggiano A, Eisen A, Iaci J, Stanulis R, Parry T, Mosedale M, Watkins PB. Longo DM, et al. Among authors: siler sq. Clin Pharmacol Ther. 2017 Dec;102(6):961-969. doi: 10.1002/cpt.711. Epub 2017 May 27. Clin Pharmacol Ther. 2017. PMID: 28419467 Free PMC article.

8

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.

Battista C, Yang K, Stahl SH, Mettetal JT, Watkins PB, Siler SQ, Howell BA. Battista C, et al. Among authors: siler sq. Toxicol Sci. 2018 Nov 1;166(1):123-130. doi: 10.1093/toxsci/kfy191. Toxicol Sci. 2018. PMID: 30060248 Free PMC article. Clinical Trial.

9

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.

Woodhead JL, Yang K, Oldach D, MacLauchlin C, Fernandes P, Watkins PB, Siler SQ, Howell BA. Woodhead JL, et al. Among authors: siler sq. Pharm Res. 2019 Feb 7;36(3):48. doi: 10.1007/s11095-019-2582-y. Pharm Res. 2019. PMID: 30734107 Free PMC article.

10

Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.

Beaudoin JJ, Yang K, Adiwidjaja J, Taneja G, Watkins PB, Siler SQ, Howell BA, Woodhead JL. Beaudoin JJ, et al. Among authors: siler sq. Front Pharmacol. 2023 Jan 17;13:1085621. doi: 10.3389/fphar.2022.1085621. eCollection 2022. Front Pharmacol. 2023. PMID: 36733378 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

32 results

Search Page