Atack JR - Search Results

1

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase.

Koulouris CR, Gardiner SE, Harris TK, Elvers KT, Mark Roe S, Gillespie JA, Ward SE, Grubisha O, Nicholls RA, Atack JR, Bax BD. Koulouris CR, et al. Among authors: atack jr. Commun Biol. 2022 Apr 11;5(1):346. doi: 10.1038/s42003-022-03264-5. Commun Biol. 2022. PMID: 35410329 Free PMC article.

2

Conformational flexibility within the small domain of human serine racemase.

Koulouris CR, Bax BD, Atack JR, Roe SM. Koulouris CR, et al. Among authors: atack jr. Acta Crystallogr F Struct Biol Commun. 2020 Feb 1;76(Pt 2):65-73. doi: 10.1107/S2053230X20001193. Epub 2020 Feb 3. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32039887 Free PMC article.

3

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase.

Fenn GD, Waller-Evans H, Atack JR, Bax BD. Fenn GD, et al. Among authors: atack jr. Acta Crystallogr F Struct Biol Commun. 2020 Oct 1;76(Pt 10):469-476. doi: 10.1107/S2053230X20011310. Epub 2020 Sep 15. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 33006574 Free PMC article.

4

A toolkit for the identification of NEAT1_2/paraspeckle modulators.

An H, Elvers KT, Gillespie JA, Jones K, Atack JR, Grubisha O, Shelkovnikova TA. An H, et al. Among authors: atack jr. Nucleic Acids Res. 2022 Nov 11;50(20):e119. doi: 10.1093/nar/gkac771. Nucleic Acids Res. 2022. PMID: 36099417 Free PMC article.

5

Subtype Selective γ-Aminobutyric Acid Type A Receptor (GABA_AR) Modulators Acting at the Benzodiazepine Binding Site: An Update.

Maramai S, Benchekroun M, Ward SE, Atack JR. Maramai S, et al. Among authors: atack jr. J Med Chem. 2020 Apr 9;63(7):3425-3446. doi: 10.1021/acs.jmedchem.9b01312. Epub 2019 Dec 5. J Med Chem. 2020. PMID: 31738537 Review.

6

Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.

Collins R, Lee H, Jones DH, Elkins JM, Gillespie JA, Thomas C, Baldwin AG, Jones K, Waters L, Paine M, Atack JR, Ward SE, Grubisha O, Foley DW. Collins R, et al. Among authors: atack jr. J Med Chem. 2022 Oct 27;65(20):13705-13713. doi: 10.1021/acs.jmedchem.2c00751. Epub 2022 Oct 7. J Med Chem. 2022. PMID: 36205722 Free PMC article.

7

African trypanosomiasis: Synthesis & SAR enabling novel drug discovery of ubiquinol mimics for trypanosome alternative oxidase.

West RA, O'Doherty OG, Askwith T, Atack J, Beswick P, Laverick J, Paradowski M, Pennicott LE, Rao SPS, Williams G, Ward SE. West RA, et al. Eur J Med Chem. 2017 Dec 1;141:676-689. doi: 10.1016/j.ejmech.2017.09.067. Epub 2017 Oct 6. Eur J Med Chem. 2017. PMID: 29107420 Free PMC article.

8

Pharmacological characterisation of MDI-222, a novel AMPA receptor positive allosteric modulator with an improved safety profile.

Ward SE, Harries MH, Aldegheri L, Bradford AM, Ballini E, Dawson L, Lacroix L, Pardoe J, Starr K, Weil A, Waters K, Atack JR, Woolley M. Ward SE, et al. Among authors: atack jr. J Psychopharmacol. 2020 Jan;34(1):93-102. doi: 10.1177/0269881119872198. Epub 2019 Nov 26. J Psychopharmacol. 2020. PMID: 31766938 Free PMC article.

9

Mode of action of DNA-competitive small molecule inhibitors of tyrosyl DNA phosphodiesterase 2.

Hornyak P, Askwith T, Walker S, Komulainen E, Paradowski M, Pennicott LE, Bartlett EJ, Brissett NC, Raoof A, Watson M, Jordan AM, Ogilvie DJ, Ward SE, Atack JR, Pearl LH, Caldecott KW, Oliver AW. Hornyak P, et al. Among authors: atack jr. Biochem J. 2016 Jul 1;473(13):1869-79. doi: 10.1042/BCJ20160180. Epub 2016 Apr 20. Biochem J. 2016. PMID: 27099339 Free PMC article.

10

Development of an oligonucleotide-based fluorescence assay for the identification of tyrosyl-DNA phosphodiesterase 1 (TDP1) inhibitors.

Walker S, Meisenberg C, Bibby RA, Askwith T, Williams G, Rininsland FH, Pearl LH, Oliver AW, El-Khamisy S, Ward S, Atack JR. Walker S, et al. Among authors: atack jr. Anal Biochem. 2014 Jun 1;454(100):17-22. doi: 10.1016/j.ab.2014.03.004. Epub 2014 Mar 14. Anal Biochem. 2014. PMID: 24637157 Free PMC article.

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